Revisiting the relevance of Hirano bodies in neurodegenerative diseases

IF 4 2区医学 Q1 CLINICAL NEUROLOGY

Neuropathology and Applied Neurobiology Pub Date : 2024-04-18 DOI:10.1111/nan.12978

Koji Yoshida, Shelley L. Forrest, Shojiro Ichimata, Hidetomo Tanaka, Tomoya Kon, Maria Carmela Tartaglia, Charles H. Tator, Anthony E. Lang, Naoki Nishida, Gabor G. Kovacs

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引用次数: 0

Abstract

AimsHirano bodies (HBs) are eosinophilic pathological structures with two morphological phenotypes commonly found in the hippocampal CA1 region in Alzheimer's disease (AD). This study evaluated the prevalence and distribution of HBs in AD and other neurodegenerative diseases.MethodsThis cross‐sectional study systematically evaluated HBs in a cohort of 193 cases with major neurodegenerative diseases, including AD (n = 91), Lewy body disease (LBD, n = 87), progressive supranuclear palsy (PSP, n = 36), multiple system atrophy (MSA, n = 14) and controls (n = 26). The prevalence, number and morphology of HBs in the stratum lacunosum (HBL) and CA1 pyramidal cell layer were examined. In addition, we investigated the presence of HBs in five additional hippocampal subregions.ResultsThe morphological types of HBs in CA1 were divided into three, including a newly discovered type, and were evaluated separately, with their morphology confirmed in three dimensions: (1) classic rod‐shaped HB (CHB), (2) balloon‐shaped HB (BHB) and the newly described (3) string‐shaped HB (SHB). The prevalence of each HB type differed between disease groups: Compared with controls, for CHB in AD, AD + LBD, PSP and corticobasal degeneration, for BHB in AD + LBD and PSP, and SHB in AD + LBD and PSP were significantly increased. Regression analysis showed that CHBs were independently associated with higher Braak NFT stage, BHBs with LBD and TDP‐43 pathology, SHBs with higher Braak NFT stage, PSP and argyrophilic grain disease and HBLs with MSA.ConclusionsThis study demonstrates that HBs are associated with diverse neurodegenerative diseases and shows that morphological types appear distinctively in various conditions.

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重新审视平野体在神经退行性疾病中的相关性

目的平野体（HBs）是一种嗜酸性病理结构，有两种形态表型，常见于阿尔茨海默病（AD）的海马CA1区。本研究评估了HBs在AD和其他神经退行性疾病中的患病率和分布情况。方法本横断面研究系统评估了193例主要神经退行性疾病病例中的HBs，包括AD（91例）、路易体病（LBD，87例）、进行性核上性麻痹（PSP，36例）、多系统萎缩（MSA，14例）和对照组（26例）。我们研究了裂隙层（HBL）和 CA1 锥体细胞层中 HB 的患病率、数量和形态。结果 CA1中的HB分为三种形态类型，包括一种新发现的类型，并分别进行了评估，从三个维度确认了它们的形态：(1) 经典杆状HB（CHB）、(2) 气球状HB（BHB）和新描述的(3) 弦状HB（SHB）。不同疾病组别中每种 HB 类型的发病率均有所不同：与对照组相比，CHB在AD、AD + LBD、PSP和皮质基底变性中，BHB在AD + LBD和PSP中，SHB在AD + LBD和PSP中均显著增加。回归分析表明，CHBs 与较高的 Braak NFT 分期独立相关，BHBs 与 LBD 和 TDP-43 病理相关，SHBs 与较高的 Braak NFT 分期、PSP 和霰粒肿相关，HBLs 与 MSA 相关。

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来源期刊

Neuropathology and Applied Neurobiology 医学-病理学

CiteScore

8.20

自引率

2.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Neuropathology and Applied Neurobiology is an international journal for the publication of original papers, both clinical and experimental, on problems and pathological processes in neuropathology and muscle disease. Established in 1974, this reputable and well respected journal is an international journal sponsored by the British Neuropathological Society, one of the world leading societies for Neuropathology, pioneering research and scientific endeavour with a global membership base. Additionally members of the British Neuropathological Society get 50% off the cost of print colour on acceptance of their article.