An Injectable Nanocomposite IPN Hydrogel Based on Gelatin Methacrylate/Alginate/COF for Tissue Engineering Applications

IF 4.2 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Samin Saleki, Saied Nouri Khorasani, Shahla Khalili, Mahshid Hafezi, Mahsa Najarzadegan, Mohammad Reza Molaviyan, Mohammad Dinari, Ali Kakapour
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Abstract

The primary request nowadays is for innovative and superior scaffold designs that mimic the characteristics of native tissue in cartilage tissue engineering. GelMA/Alginate (G/A) interpenetrating polymer network (IPN) has become a popular hydrogel material for tissue engineering because of its superior mechanical and biological properties. Here, to balance the properties, a hydrogel composed of G/A and covalent organic frameworks (COF) nanoparticles is specially designed. In this study, a hydrogel of GelMA/Alginate/COF (G/A/C) with improved properties such as pore size, swelling, mechanical strength, shear-thinning behavior, and biocompatibility is produced. Furthermore, the G/A/C hydrogel facilitate the printing of complex three dimensional (3D) scaffolds. The test result demonstrates that the addition of COF up to 1% (w/w) enhances the porosity and decreases pore size (0.2 times), improves the compression strength (six times), and decreases the degradation ratio (0.05 times) and the swelling (0.3 times) compared to the G/A hydrogel sample. Besides, the cell viability test confirms the cell growth during the incubation and great biological behavior (more than 98%). The suitable performance of the G/A hydrogel containing 1% COF and its shape fidelity during the injection by 3D printer is confirmed. Nanocomposite IPN hydrogel based on G/A/C could be useful in tissue engineering applications.

Abstract Image

基于甲基丙烯酸明胶/海藻酸盐/COF 的可注射纳米复合 IPN 水凝胶在组织工程中的应用
目前,软骨组织工程学的主要要求是设计出能模拟原生组织特性的创新型优质支架。GelMA/Alginate(G/A)互穿聚合物网络(IPN)因其优越的机械和生物特性,已成为组织工程中常用的水凝胶材料。为了平衡这些特性,我们特别设计了一种由 G/A 和共价有机框架(COF)纳米颗粒组成的水凝胶。在这项研究中,制备出了一种 GelMA/Alginate/COF 水凝胶(G/A/C),其孔径、溶胀性、机械强度、剪切稀化行为和生物相容性等性能都得到了改善。此外,G/A/C 水凝胶还有助于打印复杂的三维(3D)支架。测试结果表明,与 G/A 水凝胶样品相比,添加 1%(重量比)的 COF 可提高孔隙率并减小孔径(0.2 倍),提高压缩强度(6 倍),降低降解率(0.05 倍)和膨胀率(0.3 倍)。此外,细胞活力测试证实了培养过程中细胞的生长和良好的生物学行为(超过 98%)。含有 1% COF 的 G/A 水凝胶的合适性能及其在 3D 打印机注射过程中的形状保真度也得到了证实。基于 G/A/C 的纳米复合 IPN 水凝胶可用于组织工程应用。
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来源期刊
Macromolecular Materials and Engineering
Macromolecular Materials and Engineering 工程技术-材料科学:综合
CiteScore
7.30
自引率
5.10%
发文量
328
审稿时长
1.6 months
期刊介绍: Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications. Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science. The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments. ISSN: 1438-7492 (print). 1439-2054 (online). Readership:Polymer scientists, chemists, physicists, materials scientists, engineers Abstracting and Indexing Information: CAS: Chemical Abstracts Service (ACS) CCR Database (Clarivate Analytics) Chemical Abstracts Service/SciFinder (ACS) Chemistry Server Reaction Center (Clarivate Analytics) ChemWeb (ChemIndustry.com) Chimica Database (Elsevier) COMPENDEX (Elsevier) Current Contents: Physical, Chemical & Earth Sciences (Clarivate Analytics) Directory of Open Access Journals (DOAJ) INSPEC (IET) Journal Citation Reports/Science Edition (Clarivate Analytics) Materials Science & Engineering Database (ProQuest) PASCAL Database (INIST/CNRS) Polymer Library (iSmithers RAPRA) Reaction Citation Index (Clarivate Analytics) Science Citation Index (Clarivate Analytics) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) SCOPUS (Elsevier) Technology Collection (ProQuest) Web of Science (Clarivate Analytics)
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