Grey matter alterations in generalized anxiety disorder: A voxel-wise meta-analysis of voxel-based morphometry studies

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2024-04-18 DOI:10.1002/jdn.10330

Chang-Hsien Ou, Chiu-Shih Cheng, Pei-Ling Lin, Cheng-Lung Lee

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引用次数: 0

Abstract

Objective

Grey matter, a crucial component of the brain, has been found altered in generalized anxiety disorder (GAD) of several voxel-based morphometry studies. The conclusive and consistent grey matter alterations in GAD have not been confirmed.

Method

Eleven voxel-based morphometry studies of GAD patients were included in the current systematic review and meta-analysis. The linear model of anxiety severity scores was applied to explore the relationship of grey matter alterations and anxiety severity. The subgroup analysis of adult GAD and adolescent GAD was also performed.

Results

Significantly modest grey matter alterations in the left superior temporal gyrus of patients with GAD were found. The anxiety severity score was significantly correlated with grey matter alterations in the right insula, lenticular nucleus, putamen and striatum. The subgroup analysis of adult GAD and adolescent GAD all failed to show significant grey matter alterations. However, in the adult GAD subgroup, anxiety severity score was significantly correlated with grey matter alterations in the right insula.

Conclusion

GAD might have the modest grey matter alterations in the left superior temporal gyrus. Anxiety severity might be related to the grey matter alterations in the limbic regions, such as the right insula, lenticular nucleus, putamen and striatum. This kind of correlation might be related to the effects of adult GAD. Future studies with adequate sample sizes and sophisticated GAD categories will be needed.

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广泛性焦虑症的灰质改变：基于体素形态计量学研究的体素荟萃分析

目的在多项基于体素的形态测量研究中发现，作为大脑重要组成部分的灰质在广泛性焦虑症（GAD）中发生了改变。本系统综述和荟萃分析纳入了七项针对 GAD 患者的体素形态测量研究。采用焦虑严重程度评分的线性模型来探讨灰质改变与焦虑严重程度的关系。结果发现 GAD 患者左侧颞上回的灰质发生了明显的轻度改变。焦虑严重程度评分与右侧岛叶、透镜核、普鲁士门和纹状体的灰质改变有明显相关性。成人 GAD 和青少年 GAD 的亚组分析均未显示出明显的灰质改变。然而，在成人 GAD 亚组中，焦虑严重程度评分与右侧岛叶灰质的改变呈显著相关。焦虑症的严重程度可能与边缘区的灰质改变有关，如右脑岛叶、皮褶核、丘脑和纹状体。这种相关性可能与成人 GAD 的影响有关。未来的研究需要足够的样本量和复杂的 GAD 类别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.