Undifferentiated carcinoma of the liver with osteoclast-like giant cells: a case report and literature review

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2024-04-20 DOI:10.1186/s13027-024-00582-7

Lixia Lu, Li Wang, Can Peng, Li Chen, Ximan He, Chenning Shao, Chunnian Wang, Rong Ge

引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Osteoclast-like giant cells (OGCs) are relatively more common in pancreatic cancer, but extremely rare in HCC. Currently, there have been only a few reported cases of OGCs in HCC, and their presence indicates an aggressive clinical course. Here, we present a case of primary undifferentiated carcinoma of the liver with OGCs in a 49-year-old male patient, and through a literature review, we summarize 20 similar cases to further understand the diagnosis, treatment, and clinical course of this disease entity.

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伴有破骨细胞样巨细胞的肝未分化癌：病例报告和文献综述

肝细胞癌（HCC）是肝脏中最常见的原发性恶性肿瘤。破骨细胞样巨细胞（OGCs）在胰腺癌中较为常见，但在肝细胞癌中却极为罕见。目前，HCC 中出现 OGCs 的病例报道寥寥无几，而 OGCs 的出现预示着其临床病程具有侵袭性。在此，我们介绍了一例 49 岁男性原发性肝未分化癌伴有 OGCs 的病例，并通过文献综述总结了 20 例类似病例，以进一步了解这种疾病的诊断、治疗和临床过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.