Associations among environmental exposure to trace elements and biomarkers of early kidney damage in the pediatric population

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Manolo Ortega-Romero, Elodia Rojas-Lima, Juan Carlos Rubio-Gutiérrez, Octavio Gamaliel Aztatzi-Aguilar, Juana Narváez-Morales, Mariela Esparza-García, Ángel Barrera-Hernández, Miguel Ángel Mejia, Pablo Mendez-Hernández, Mara Medeiros, Olivier Christophe Barbier
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Abstract

Background

In kidney damage, molecular changes can be used as early damage kidney biomarkers, such as Kidney Injury Molecule-1 and Neutrophil gelatinase-associated lipocalin. These biomarkers are associated with toxic metal exposure or disturbed homeostasis of trace elements, which might lead to serious health hazards. This study aimed to evaluate the relationship between exposure to trace elements and early damage kidney biomarkers in a pediatric population.

Methods

In Tlaxcala, a cross-sectional study was conducted on 914 healthy individuals. The participants underwent a medical review and a socio-environmental questionnaire. Five early damage kidney biomarkers were determined in the urine with Luminex, and molybdenum, copper, selenium, nickel, and iodine were measured with ICP-Mass.

Results

The eGFR showed a median of 103.75 mL/min/1.73 m2. The median levels for molybdenum, copper, selenium, nickel, and iodine were 24.73 ng/mL, 73.35 ng/mL, 4.78 ng/mL, 83.68 ng/mL, and 361.83 ng/mL, respectively. Except for molybdenum and nickel, the other trace elements had significant associations with the eGFR and the early kidney damage biomarkers. Additionally, we report the association of different exposure scenarios with renal parameters.

Discussion

and Conclusions.

Among the explored metals, exposure to Cu and iodine impairs renal function. In contrast, Se may manifest as a beneficial metal. Interactions of Mo-Se and Mo-Iodine seem to alter the expression of NGAL; Mo-Cu for CLU; Mo-Cu, Mo-Se, and Mo-iodine for Cys-C and a-1MG; and Mo-Cu and Mo-iodine for KIM-1; were noticed. Our study could suggest that trace element interactions were associated with early kidney damage biomarkers.

Abstract Image

环境中微量元素暴露与儿童早期肾损伤生物标志物之间的关系
背景在肾脏损伤中,分子变化可作为早期损伤肾脏的生物标志物,如肾损伤分子-1(Kidney Injury Molecule-1)和中性粒细胞明胶酶相关脂褐素(Neutrophil gelatinase-associated lipocalin)。这些生物标志物与有毒金属暴露或微量元素平衡紊乱有关,可能会导致严重的健康危害。本研究旨在评估儿科人群接触微量元素与早期损伤肾脏生物标志物之间的关系。方法在特拉斯卡拉对 914 名健康人进行了横断面研究。参与者接受了医疗检查和社会环境问卷调查。用 Luminex 测定了尿液中的五种早期肾损伤生物标志物,并用 ICP-Mass 测定了钼、铜、硒、镍和碘。钼、铜、硒、镍和碘的中位数分别为 24.73 纳克/毫升、73.35 纳克/毫升、4.78 纳克/毫升、83.68 纳克/毫升和 361.83 纳克/毫升。除钼和镍外,其他微量元素均与肾小球滤过率和早期肾损伤生物标志物有显著关联。此外,我们还报告了不同暴露情况与肾脏参数的关联。相比之下,硒可能是一种有益的金属。我们注意到,钼-硒和钼-碘似乎会改变 NGAL 的表达;钼-铜会影响 CLU;钼-铜、钼-硒和钼-碘会影响 Cys-C 和 a-1MG;钼-铜和钼-碘会影响 KIM-1。我们的研究表明,微量元素之间的相互作用与早期肾损伤生物标志物有关。
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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