Efficacy of Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Wounds: A Retrospective Observational Study

IF 1.5 4区医学 Q3 DERMATOLOGY

International Journal of Lower Extremity Wounds Pub Date : 2024-04-17 DOI:10.1177/15347346241243102

Abdulkadir Calavul

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Abstract

BackgroundChronic wounds, including diabetic ulcers, posttraumatic ulcers, and pressure sores, present a significant challenge in healthcare due to their complex nature and resistance to conventional treatments. This retrospective observational study aimed to evaluate the efficacy of an ointment containing hyaluronic acid and collagenase in treating such wounds.MethodsThe study included 70 patients with various chronic wounds treated in our clinic from January 1, 2020, to October 1, 2023. The patients were selected according to specific inclusion and exclusion criteria, and comprehensive baseline data was collected. The treatment involved the application of a hyaluronic acid and collagenase ointment, followed by regular follow-up and data analysis.ResultsSignificant improvements in wound bed scores (WBS) were observed, with a reduction in healing times for all types of wounds. High patient satisfaction rates were reported, along with efficient debridement and notable pain reduction. Diabetic ulcers showed the most significant improvement in terms of healing time and WBS.ConclusionsHyaluronic acid and collagenase ointment demonstrated promising results in the treatment of chronic wounds. This treatment may offer a valuable addition to current wound care practices, particularly in challenging cases such as diabetic ulcers. More research is recommended, including randomized controlled trials, to validate these findings.

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透明质酸/胶原酶软膏治疗慢性伤口的疗效：回顾性观察研究

背景慢性伤口，包括糖尿病溃疡、创伤后溃疡和压疮，由于其复杂性和对常规治疗的耐受性，给医疗保健带来了巨大挑战。这项回顾性观察研究旨在评估一种含有透明质酸和胶原酶的软膏在治疗此类伤口方面的疗效。方法该研究纳入了自 2020 年 1 月 1 日至 2023 年 10 月 1 日在本诊所接受治疗的 70 名患有各种慢性伤口的患者。根据特定的纳入和排除标准选择患者，并收集了全面的基线数据。治疗过程包括涂抹透明质酸和胶原酶软膏，然后进行定期随访和数据分析。结果观察到伤口床评分（WBS）显著改善，所有类型伤口的愈合时间都缩短了。患者满意度高，清创效率高，疼痛明显减轻。结论透明质酸和胶原酶软膏在治疗慢性伤口方面效果显著。这种治疗方法可为当前的伤口护理实践提供有价值的补充，尤其是在糖尿病溃疡等具有挑战性的病例中。建议开展更多研究，包括随机对照试验，以验证这些发现。

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来源期刊

International Journal of Lower Extremity Wounds DERMATOLOGY-SURGERY

CiteScore

4.60

自引率

17.60%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).