The role of the fibroblast in Barrett's esophagus and esophageal adenocarcinoma.

IF 2.6 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Current Opinion in Gastroenterology Pub Date : 2024-04-12 DOI:10.1097/mog.0000000000001032

Huili Zhu, Ramon U Jin

引用次数: 0

Abstract

Barrett's esophagus (BE) is the number one risk factor for developing esophageal adenocarcinoma (EAC), a deadly cancer with limited treatment options that has been increasing in incidence in the US. In this report, we discuss current studies on the role of mesenchyme and cancer-associated fibroblasts (CAFs) in BE and EAC, and we highlight translational prospects of targeting these cells.

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成纤维细胞在巴雷特食管和食管腺癌中的作用。

巴雷特食管（Barrett's esophagus，BE）是食管腺癌（EAC）的头号危险因素，EAC是一种致命的癌症，治疗方法有限，在美国的发病率不断上升。在本报告中，我们将讨论目前有关间质和癌相关成纤维细胞（CAFs）在BE和EAC中作用的研究，并重点介绍靶向这些细胞的转化前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Gastroenterology 医学-胃肠肝病学

CiteScore

5.30

自引率

0.00%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Published bimonthly and offering a unique and wide ranging perspective on the key developments in the field, each issue of Current Opinion in Gastroenterology features hand-picked review articles from our team of expert editors. With twelve disciplines published across the year – including gastrointestinal infections, nutrition and inflammatory bowel disease – every issue also contains annotated references detailing the merits of the most important papers.