A new resorcylic acid lactone from the endophytic fungus Chaetosphaeronema sp.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-04-16 DOI:10.1080/10286020.2024.2335254

Min Wang , Gui-Yang Xia , Yong-Xin Liang , Huan Xia , Peng-Cheng Lin , Sheng Lin

引用次数: 0

Abstract

A new 14-membered resorcylic acid lactone (RAL₁₄), chaetolactone A (1), along with three known ones (2−4), was obtained from the fermentation of the soil-derived fungus Chaetosphaeronema sp. SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),¹³C NMR chemical shifts calculations coupled with the DP4⁺ probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic effects against A549, HO-8910, and MCF-7 cell lines.

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来自内生真菌 Chaetosphaeronema sp.

从土壤源真菌 Chaetosphaeronema sp. SSJZ00 的发酵中获得了一种新的 14 元残基酸内酯 (RAL14)--Chaetolactone A (1)，以及三种已知的内酯 (2-4)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.