Preliminary Exploration of the Biophysical Mechanisms of Pulsed Magnetic Field- Induced Cell Permeabilization

IF 3.7 4区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

IEEE Transactions on NanoBioscience Pub Date : 2024-04-16 DOI:10.1109/TNB.2024.3385413

Chi Ma;Mengnan Zhang;Fei Teng;Wei Zheng;Yan Mi

{"title":"Preliminary Exploration of the Biophysical Mechanisms of Pulsed Magnetic Field- Induced Cell Permeabilization","authors":"Chi Ma;Mengnan Zhang;Fei Teng;Wei Zheng;Yan Mi","doi":"10.1109/TNB.2024.3385413","DOIUrl":null,"url":null,"abstract":"Pulsed magnetic field treatment can enhance cell membrane permeability, allowing large molecular substances that normally cannot pass through the cell membrane to enter the cell. This research holds significant prospects for biomedical applications. However, the mechanism underlying pulsed magnetic field-induced cell permeabilization remains unclear, impeding further progress in research related to pulsed magnetic field. Currently, hypotheses about the mechanism are struggling to explain experimental results. Therefore, this study developed a parameter-adjustable pulsed magnetic field generator and designed experiments. Starting from the widely accepted hypothesis of “induced electric fields by pulsed magnetic field,” we conducted a preliminary exploration of the biophysical mechanisms underlying pulsed magnetic field-induced cell permeabilization. Finally, we have arrived at an intriguing conclusion: under the current technical parameters, the impact of the pulsed magnetic field itself is the primary factor influencing changes in cell membrane permeability, rather than the induced electric field. This conclusion holds significant implications for understanding the biophysical mechanisms behind pulsed magnetic field therapy and its potential biomedical applications.","PeriodicalId":13264,"journal":{"name":"IEEE Transactions on NanoBioscience","volume":"23 3","pages":"482-490"},"PeriodicalIF":3.7000,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on NanoBioscience","FirstCategoryId":"99","ListUrlMain":"https://ieeexplore.ieee.org/document/10499243/","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 0

Abstract

Pulsed magnetic field treatment can enhance cell membrane permeability, allowing large molecular substances that normally cannot pass through the cell membrane to enter the cell. This research holds significant prospects for biomedical applications. However, the mechanism underlying pulsed magnetic field-induced cell permeabilization remains unclear, impeding further progress in research related to pulsed magnetic field. Currently, hypotheses about the mechanism are struggling to explain experimental results. Therefore, this study developed a parameter-adjustable pulsed magnetic field generator and designed experiments. Starting from the widely accepted hypothesis of “induced electric fields by pulsed magnetic field,” we conducted a preliminary exploration of the biophysical mechanisms underlying pulsed magnetic field-induced cell permeabilization. Finally, we have arrived at an intriguing conclusion: under the current technical parameters, the impact of the pulsed magnetic field itself is the primary factor influencing changes in cell membrane permeability, rather than the induced electric field. This conclusion holds significant implications for understanding the biophysical mechanisms behind pulsed magnetic field therapy and its potential biomedical applications.

查看原文本刊更多论文

脉冲磁场诱导细胞渗透的生物物理机制初探

脉冲磁场处理可增强细胞膜的通透性，使通常无法通过细胞膜的大分子物质进入细胞。这项研究在生物医学应用方面前景广阔。然而，脉冲磁场诱导细胞通透性的机制仍不清楚，阻碍了脉冲磁场相关研究的进一步发展。目前，有关该机制的假设很难解释实验结果。因此，本研究开发了一种参数可调的脉冲磁场发生器，并设计了实验。从 "脉冲磁场诱导电场 "这一广为接受的假说出发，我们对脉冲磁场诱导细胞通透的生物物理机制进行了初步探索。最后，我们得出了一个耐人寻味的结论：在目前的技术参数下，脉冲磁场本身的影响是影响细胞膜通透性变化的主要因素，而不是诱导电场。这一结论对于理解脉冲磁场疗法背后的生物物理机制及其潜在的生物医学应用具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

IEEE Transactions on NanoBioscience 工程技术-纳米科技

CiteScore

7.00

自引率

5.10%

发文量

197

审稿时长

>12 weeks

期刊介绍： The IEEE Transactions on NanoBioscience reports on original, innovative and interdisciplinary work on all aspects of molecular systems, cellular systems, and tissues (including molecular electronics). Topics covered in the journal focus on a broad spectrum of aspects, both on foundations and on applications. Specifically, methods and techniques, experimental aspects, design and implementation, instrumentation and laboratory equipment, clinical aspects, hardware and software data acquisition and analysis and computer based modelling are covered (based on traditional or high performance computing - parallel computers or computer networks).