Andrea Madabeni, Thomas Scattolin, Enrica Bortolamiol, Fabiano Visentin and Laura Orian*,
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引用次数: 0
Abstract
Palladium complexes are emerging as potential antitumor compounds. Recent experimental evidence suggests that the mechanism of action of some organopalladium derivatives might involve the target of proteins such as Thioredoxin Reductase (TrxR). In this work, we investigate different possible chemical mechanisms of interaction between selected palladium(II)-η3-allyl complexes and thiolates or selenolates, which are key functional groups present in the catalytic pocket of TrxR. Our investigation, focusing on both anionic and cationic complexes, suggests that in all cases, the interaction between the organopalladium species and chalcogenolates occurs via a ligand exchange reaction, which leads to the formation of a new Pd–S or Pd–Se bond. Allyl substitution, which takes place with the formation of a new C–S or C–Se bond, always appears to be the least favored reaction, from both the kinetic and thermodynamic points of view.
期刊介绍:
Organometallics is the flagship journal of organometallic chemistry and records progress in one of the most active fields of science, bridging organic and inorganic chemistry. The journal publishes Articles, Communications, Reviews, and Tutorials (instructional overviews) that depict research on the synthesis, structure, bonding, chemical reactivity, and reaction mechanisms for a variety of applications, including catalyst design and catalytic processes; main-group, transition-metal, and lanthanide and actinide metal chemistry; synthetic aspects of polymer science and materials science; and bioorganometallic chemistry.