Evaluation of the anticancer effects exerted by 5-fluorouracil and heme oxygenase-1 inhibitor hybrids in HTC116 colorectal cancer cells

IF 5.6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Enzyme Inhibition and Medicinal Chemistry Pub Date : 2024-04-18 DOI:10.1080/14756366.2024.2337191

Loredana Salerno, Antonietta Notaro, Valeria Consoli, Federica Affranchi, Valeria Pittalà, Valeria Sorrenti, Luca Vanella, Michela Giuliano, Sebastiano Intagliata

引用次数: 0

Abstract

Colon cancer remains a clinical challenge in industrialised countries. Its treatment with 5-Flurouracil (5-FU) develops many side effects and resistance. Thus, several strategies have been undertak...

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评估 5-氟尿嘧啶和血红素加氧酶-1 抑制剂混合物在 HTC116 大肠癌细胞中发挥的抗癌作用

在工业化国家，结肠癌仍然是一项临床难题。使用 5-氟尿嘧啶（5-FU）治疗结肠癌会产生许多副作用和耐药性。因此，人们采取了多种策略...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Enzyme Inhibition and Medicinal Chemistry 医学-生化与分子生物学

CiteScore

10.30

自引率

10.70%

发文量

195

审稿时长

4-8 weeks

期刊介绍： Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research. The journal’s focus includes current developments in: Enzymology; Cell biology; Chemical biology; Microbiology; Physiology; Pharmacology leading to drug design; Molecular recognition processes; Distribution and metabolism of biologically active compounds.