Incidence of chemotherapy-related cardiac dysfunction in cancer patients

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Hai-Wei Deng MD, Rui Fan MD, Yuan-Sheng Zhai MD, Jie Li MD, Zhi-Bin Huang MD, PhD, Long-Yun Peng MD, PhD
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Abstract

Background

Cancer patients are increasingly affected by chemotherapy-related cardiac dysfunction. The reported incidence of this condition vary significantly across different studies.

Hypothesis

A better comprehensive understanding of chemotherapy-related cardiac dysfunction incidence in cancer patients is imperative. Therefore, we performed a meta-analysis to establish the overall incidence of chemotherapy-related cardiac dysfunction in cancer patients.

Methods

We searched articles in PubMed and EMBASE from database inception to May 1, 2023. Studies that reported the incidence of chemotherapy-related cardiac dysfunction in cancer patients were included.

Results

A total of 53 studies involving 35 651 individuals were finally included in the meta-analysis. The overall pooled incidence of chemotherapy-related cardiac dysfunction in cancer patients was 63.21 per 1000 person-years (95% CI: 57.28−69.14). The chemotherapy-related cardiac dysfunction incidence increased steeply within half a year of cancer chemotherapy. Also, the trend of chemotherapy-related cardiac dysfunction incidence appeared to have plateaued after a longer duration of follow-up. In addition, chemotherapy-related cardiac dysfunction incidence rates are significantly higher among patients with age ≥50 years versus patients with age <50 years (99.96 vs. 34.48 per 1000 person-years). The incidence rate of cardiac dysfunction was higher among breast cancer patients (72.97 per 1000 person-years), leukemia patients (65.21 per 1000 person-years), and lymphoma patients (55.43 per 1000 person-years).

Conclusion

Our meta-analysis unveiled a definitive overall incidence rate of chemotherapy-related cardiac dysfunction in cancer patients. In addition, it was found that the risk of developing this condition escalates within the initial 6 months postchemotherapy, subsequently tapering off to become statistically insignificant after a duration of 6 years.

Abstract Image

癌症患者化疗相关心功能障碍的发生率
背景 癌症患者越来越多地受到化疗相关心功能障碍的影响。不同研究报告的发病率差异很大。 假设 当务之急是更好地全面了解癌症患者化疗相关心功能不全的发生率。因此,我们进行了一项荟萃分析,以确定癌症患者化疗相关心功能不全的总体发生率。 方法 我们检索了自数据库建立至 2023 年 5 月 1 日期间在 PubMed 和 EMBASE 上发表的文章。纳入了报告癌症患者化疗相关心功能障碍发生率的研究。 结果 共有53项研究(涉及35 651人)最终被纳入荟萃分析。癌症患者化疗相关心功能障碍的总发病率为每千人年 63.21 例(95% CI:57.28-69.14)。化疗相关心功能障碍的发生率在癌症化疗后半年内急剧上升。而且,在较长时间的随访后,化疗相关心功能不全发生率的趋势似乎趋于平稳。此外,年龄≥50岁的患者与年龄<50岁的患者相比,化疗相关心功能不全的发生率明显更高(99.96 vs. 34.48 per 1000 person-years)。乳腺癌患者(72.97 人/1000 年)、白血病患者(65.21 人/1000 年)和淋巴瘤患者(55.43 人/1000 年)的心功能不全发生率更高。 结论 我们的荟萃分析揭示了癌症患者化疗相关心功能障碍的总发病率。此外,研究还发现,在化疗后的最初 6 个月内,出现这种情况的风险会上升,随后会逐渐降低,在持续 6 年后,这种风险在统计学上将变得微不足道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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