Memory effects in disease modelling through kernel estimates with oscillatory time history

IF 2.2 4区 数学 Q2 BIOLOGY
Adam Mielke, Mads Peter Sørensen, John Wyller
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引用次数: 0

Abstract

We design a linear chain trick algorithm for dynamical systems for which we have oscillatory time histories in the distributed time delay. We make use of this algorithmic framework to analyse memory effects in disease evolution in a population. The modelling is based on a susceptible-infected-recovered SIR—model and on a susceptible-exposed-infected-recovered SEIR—model through a kernel that dampens the activity based on the recent history of infectious individuals. This corresponds to adaptive behavior in the population or through governmental non-pharmaceutical interventions. We use the linear chain trick to show that such a model may be written in a Markovian way, and we analyze the stability of the system. We find that the adaptive behavior gives rise to either a stable equilibrium point or a stable limit cycle for a close to constant number of susceptibles, i.e. locally in time. We also show that the attack rate for this model is lower than it would be without the dampening, although the adaptive behavior disappears as time goes to infinity and the number of infected goes to zero.

通过具有振荡时间历程的核估计建立疾病模型的记忆效应
我们为分布式时间延迟中具有振荡时间历史的动态系统设计了一种线性链技巧算法。我们利用这一算法框架来分析种群中疾病演化的记忆效应。建模基于易感-感染-恢复的 SIR 模型和易感-暴露-感染-恢复的 SEIR 模型,通过内核根据感染个体的近期历史抑制活动。这相当于人群中的适应行为或通过政府的非药物干预。我们使用线性链技巧来证明这种模型可以用马尔可夫方法来书写,并分析了系统的稳定性。我们发现,在易感人群数量接近恒定的情况下,即在局部时间内,自适应行为会产生一个稳定的平衡点或一个稳定的极限循环。我们还证明,虽然随着时间的无穷大和受感染者数量的归零,自适应行为会消失,但该模型的攻击率比没有阻尼时要低。
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来源期刊
CiteScore
3.30
自引率
5.30%
发文量
120
审稿时长
6 months
期刊介绍: The Journal of Mathematical Biology focuses on mathematical biology - work that uses mathematical approaches to gain biological understanding or explain biological phenomena. Areas of biology covered include, but are not restricted to, cell biology, physiology, development, neurobiology, genetics and population genetics, population biology, ecology, behavioural biology, evolution, epidemiology, immunology, molecular biology, biofluids, DNA and protein structure and function. All mathematical approaches including computational and visualization approaches are appropriate.
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