The association between glymphatic system dysfunction and alterations in cerebral function and structure in patients with white matter hyperintensities.

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2024-04-10 DOI:10.1097/wnr.0000000000002031

Zhang Zhi, Xiao Liang, Muhua Huang, Lin Wu, Fuqing Zhou

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Abstract

The objective of this study is to explore the relationship between the glymphatic system and alterations in the structure and function of the brain in white matter hyperintensity (WMH) patients. MRI data were collected from 27 WMH patients and 23 healthy controls. We calculated the along perivascular space (ALPS) indices, the anterior corner distance of the lateral ventricle, and the width of the third ventricle for each subject. The DPABISurf tool was used to calculate the cortical thickness and cortical area. In addition, data processing assistant for resting-state fMRI was used to calculate regional homogeneity, degree centrality, amplitude low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF), and voxel-mirrored homotopic connectivity (VMHC). In addition, each WMH patient was evaluated on the Fazekas scale. Finally, the correlation analysis of structural indicators and functional indicators with bilateral ALPS indices was investigated using Spearman correlation analysis. The ALPS indices of WMH patients were lower than those of healthy controls (left: t = -4.949, P < 0.001; right: t = -3.840, P < 0.001). This study found that ALFF, fALFF, regional homogeneity, degree centrality, and VMHC values in some brain regions of WMH patients were alternated (AlphaSim corrected, P < 0.005, cluster size > 26 voxel, rmm value = 5), and the cortical thickness and cortical area of WMH patients showed trend changes (P < 0.01, cluster size > 20 mm2, uncorrected). Interestingly, we found significantly positive correlations between the left ALPS indices and degree centrality values in the superior temporal gyrus (r = 0.494, P = 0.009, P × 5 < 0.05, Bonferroni correction). Our results suggest that glymphatic system impairment is related to the functional centrality of local connections in patients with WMH. This provides a new perspective for understanding the pathological mechanisms of cognitive impairment in the WMH population.

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脑白质增生症患者的淋巴系统功能障碍与大脑功能和结构改变之间的关联。

本研究的目的是探讨脑白质高密度症（WMH）患者的甘油系统与大脑结构和功能改变之间的关系。研究收集了 27 名 WMH 患者和 23 名健康对照者的磁共振成像数据。我们计算了每个受试者的沿血管周围空间（ALPS）指数、侧脑室前角距离和第三脑室宽度。我们使用 DPABISurf 工具计算皮质厚度和皮质面积。此外，还使用静息态 fMRI 数据处理助手计算区域同质性、度中心性、低频波动幅度（ALFF）、低频波动分数幅度（fALFF）和体素镜像同位连接性（VMHC）。此外，还对每位 WMH 患者进行了法泽卡斯量表评估。最后，利用斯皮尔曼相关分析法研究了结构指标和功能指标与双侧 ALPS 指数的相关性分析。WMH患者的ALPS指数低于健康对照组（左侧：t = -4.949，P < 0.001；右侧：t = -3.840，P < 0.001）。本研究发现，WMH患者部分脑区的ALFF、fALFF、区域同质性、度中心性和VMHC值呈交替变化（AlphaSim校正，P < 0.005，聚类大小> 26体素，rmm值=5），WMH患者的皮层厚度和皮层面积呈趋势性变化（P <0.01，聚类大小> 20平方毫米，未校正）。有趣的是，我们发现左侧 ALPS 指数与颞上回的度中心性值之间存在明显的正相关（r = 0.494，P = 0.009，P × 5 < 0.05，Bonferroni 校正）。我们的研究结果表明，WMH 患者的脑 glymphatic 系统损伤与局部连接的功能中心性有关。这为了解 WMH 患者认知功能障碍的病理机制提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.