The Different Shades of Thermogenic Adipose Tissue

IF 9.5 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Obesity Reports Pub Date : 2024-04-12 DOI:10.1007/s13679-024-00559-y

Yunwen Hu, Yijie Huang, Yangjing Jiang, Lvkan Weng, Zhaohua Cai, Ben He

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引用次数: 0

Abstract

Purpose of Review

By providing a concise overview of adipose tissue types, elucidating the regulation of adipose thermogenic capacity in both physiological contexts and chronic wasting diseases (a protracted hypermetabolic state that precipitates sustained catabolism and consequent progressive corporeal atrophy), and most importantly, delving into the ongoing discourse regarding the role of adipose tissue thermogenic activation in chronic wasting diseases, this review aims to provide researchers with a comprehensive understanding of the field.

Recent Findings

Adipose tissue, traditionally classified as white, brown, and beige (brite) based on its thermogenic activity and potential, is intricately regulated by complex mechanisms in response to exercise or cold exposure. This regulation is adipose depot-specific and dependent on the duration of exposure. Excessive thermogenic activation of adipose tissue has been observed in chronic wasting diseases and has been considered a pathological factor that accelerates disease progression. However, this conclusion may be confounded by the detrimental effects of excessive lipolysis. Recent research also suggests that such activation may play a beneficial role in the early stages of chronic wasting disease and provide potential therapeutic effects.

Summary

A more comprehensive understanding of the changes in adipose tissue thermogenesis under physiological and pathological conditions, as well as the underlying regulatory mechanisms, is essential for the development of novel interventions to improve health and prevent disease.

Abstract Image

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不同颜色的致热脂肪组织

综述目的本综述简要概述了脂肪组织的类型，阐明了在生理环境和慢性消耗性疾病（一种长期的高代谢状态，会导致持续的分解代谢和随之而来的渐进性肉体萎缩）中脂肪组织生热能力的调控，最重要的是，深入探讨了脂肪组织生热激活在慢性消耗性疾病中的作用，旨在为研究人员提供对该领域的全面了解。最新研究结果脂肪组织传统上根据其生热活性和潜力被分为白色、棕色和米色脂肪组织，它们在运动或寒冷暴露时受到复杂机制的调控。这种调节具有脂肪库特异性，并取决于暴露时间的长短。在慢性消耗性疾病中观察到脂肪组织的过度生热激活，这被认为是加速疾病进展的病理因素。然而，这一结论可能会被过度脂肪分解的有害影响所混淆。最近的研究还表明，这种激活可能在慢性消耗性疾病的早期阶段发挥有益的作用，并提供潜在的治疗效果。摘要更全面地了解脂肪组织产热在生理和病理条件下的变化以及潜在的调节机制，对于开发新型干预措施以改善健康和预防疾病至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Obesity Reports Medicine-General Medicine

CiteScore

16.40

自引率

1.10%

发文量

期刊介绍： The main objective of Current Obesity Reports is to provide expert review articles on recent advancements in the interdisciplinary field of obesity research. Our aim is to offer clear, insightful, and balanced contributions that will benefit all individuals involved in the treatment and prevention of obesity, as well as related conditions such as cardiovascular diseases, endocrine disorders, gynecological issues, cancer, mental health, respiratory complications, and rheumatological diseases. We strive to redefine the way knowledge is expressed and provide organized content for the benefit of our readership.