Hamta Majd, Merve Gultekinoglu, Cem Bayram, Beren Karaosmanoğlu, Ekim Z. Taşkıran, Didem Kart, Özgür Doğuş Erol, Anthony Harker, Mohan Edirisinghe
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引用次数: 0
Abstract
This work explores the application of Allium sativum (Garlic) extract, in the creation of novel polymeric core-sheath fibers for wound therapy applications. The core-sheath pressurized gyration (CS PG) technology is utilized to mass-produce fibers with a polycaprolactone (PCL) core and a polyethylene oxide (PEO) sheath, loaded with garlic extract. The produced fibers maintain structural integrity, long-term stability and provide a cell-friendly surface with rapid antibacterial activity. The physical properties, morphology, therapeutic delivery, cytotoxicity, thermal and chemical stability of PCL, PEO, PEO/Garlic, Core-Sheath (CS) PEO/PCL and PEO/Garlic/PCL fibers are analyzed. Findings show that the addition of garlic extract greatly increases the fibers’ thermal durability, while decreasing their diameter, thus improving cell adhesion and proliferation. In-vitro release tests reveal a rapid release of garlic extract, which has significant antibacterial action against both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus) bacteria species. Cell viability experiments validate the fiber samples' biocompatibility and nontoxicity, making them appropriate for integrative medicine applications. These core-sheath structures emphasize the potential of combining natural therapeutic agents with advanced material technologies to develop cost-effective, sustainable and highly effective wound dressings, offering a promising solution to the growing concerns associated with conventional synthetic antibacterial agents.
期刊介绍:
Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications.
Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science.
The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments.
ISSN: 1438-7492 (print). 1439-2054 (online).
Readership:Polymer scientists, chemists, physicists, materials scientists, engineers
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