Impact of a family history of mental disorders on the characteristics of patients with early psychosis

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2024-04-04 DOI:10.1111/eip.13525

Barbara Pöthe, Philippe Conus, Philippe Golay

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Abstract

Aim

Children of parents with psychiatric illness have a higher risk of developing psychiatric disorders. This is particularly the case for psychoses and the evolution of these disorders could likely differ. The aim of this study was to study the impact of a first-degree and second-degree family history of psychiatric disorders (FHPD) on the characteristics of patients with early psychosis in a specialized programme.

Method

This research is a prospective study based on 408 patients aged 18–35 years enrolled in the Treatment and Early Intervention in Psychosis Program (TIPP) with a three-years follow-up. Various characteristics were compared between patients with first-degree-FHPD and those without, then between patients with 2nd degree-FHPD and those without. The influence of the number of parents with first or second degree FHPD on clinical characteristics was also studied.

Results

Our results showed an influence of FHPD on the characteristics of patients presenting a first episode of psychosis. Over the 3 years of follow-up, patients with at least one second-degree relative showed more negative and depressive symptoms and poorer general functioning than patient who did not. The number of parents with first or second degree FHPD was also negatively associated with several clinical variables.

Conclusion

The results of this study confirm the existence of a distinct premorbid profile and a different evolution in patients with FHPD, which is not limited to first-degree relatives. This suggests the importance of specific needs that should be addressed during treatment.

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精神病家族史对早期精神病患者特征的影响

目的父母患有精神病的儿童患精神病的风险较高。精神病的情况尤其如此，而且这些疾病的演变过程可能会有所不同。本研究旨在研究一级和二级精神病家族史（FHPD）对专业项目中早期精神病患者特征的影响。方法本研究是一项前瞻性研究，研究对象是 408 名年龄在 18-35 岁之间、参加了精神病治疗和早期干预项目（TIPP）并接受了三年随访的患者。研究比较了一级高血压病患者和非一级高血压病患者的各种特征，然后又比较了二级高血压病患者和非二级高血压病患者的各种特征。结果我们的研究结果表明，FHPD 对首次发作的精神病患者的特征有影响。在 3 年的随访中，与没有二级亲属关系的患者相比，至少有一名二级亲属关系的患者表现出更多的消极和抑郁症状，一般功能也更差。结论：本研究结果证实，FHPD 患者在发病前有独特的病史特征，其病情发展也不尽相同，这并不局限于一级亲属。这表明在治疗过程中应满足特定需求的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.