Current Trends and Challenges of Microbiome Research in Prostate Cancer

IF 4.7 2区 医学 Q1 ONCOLOGY
Shaun Trecarten, Bernard Fongang, Michael Liss
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引用次数: 0

Abstract

Purpose of Review

The role of the gut microbiome in prostate cancer is an emerging area of research interest. However, no single causative organism has yet been identified. The goal of this paper is to examine the role of the microbiome in prostate cancer and summarize the challenges relating to methodology in specimen collection, sequencing technology, and interpretation of results.

Recent Findings

Significant heterogeneity still exists in methodology for stool sampling/storage, preservative options, DNA extraction, and sequencing database selection/in silico processing. Debate persists over primer choice in amplicon sequencing as well as optimal methods for data normalization. Statistical methods for longitudinal microbiome analysis continue to undergo refinement.

Summary

While standardization of methodology may help yield more consistent results for organism identification in prostate cancer, this is a difficult task due to considerable procedural variation at each step in the process. Further reproducibility and methodology research is required.

前列腺癌微生物组研究的当前趋势与挑战
综述目的 肠道微生物组在前列腺癌中的作用是一个新兴的研究领域。然而,目前尚未发现单一的致病微生物。本文旨在研究微生物组在前列腺癌中的作用,并总结与标本采集方法、测序技术和结果解释有关的挑战。最新研究结果粪便取样/储存、防腐剂选择、DNA 提取和测序数据库选择/硅处理的方法仍存在显著的不一致性。关于扩增子测序中引物的选择以及数据归一化的最佳方法仍存在争议。纵向微生物组分析的统计方法仍在不断完善中。摘要虽然方法的标准化可能有助于在前列腺癌的生物鉴定中获得更一致的结果,但由于过程中每个步骤的程序差异很大,因此这是一项艰巨的任务。需要进一步开展可重复性和方法学研究。
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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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