Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-04-05 DOI:10.2174/0115680266304711240327072348

Surinya Traipop, Whitchuta Jesadabundit, Wisarut Khamcharoen, Tavechai Pholsiri, Sarida Naorungroj, Sakda Jampasa, Orawon Chailapakul

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Abstract

:: This review explores the advancements in nanomaterial-based electrochemical sensors for the multiplex detection of medicinal compounds. The growing demand for efficient and selective detection methods in the pharmaceutical field has prompted significant research into the development of electrochemical sensors employing nanomaterials. These materials, defined as functional materials with at least one dimension between 1 and 100 nanometers, encompass metal nanoparticles, polymers, carbon-based nanocomposites, and nano-bioprobes. These sensors are characterized by their enhanced sensitivity and selectivity, playing a crucial role in simultaneous detection and offering a comprehensive analysis of multiple medicinal complexes within a single sample. The review comprehensively examines the design, fabrication, and application of nanomaterial- based electrochemical sensors, focusing on their ability to achieve multiplex detection of various medicinal substances. Insights into the strategies and nanomaterials employed for enhancing sensor performance are discussed. Additionally, the review explores the challenges and future perspectives of this evolving field, highlighting the potential impact of nanomaterial-based electrochemical sensors on the advancement of medicinal detection technologies.

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基于纳米材料的多重药物应用电化学传感器

::本综述探讨了基于纳米材料的电化学传感器在药用化合物多重检测方面取得的进展。制药领域对高效和选择性检测方法的需求日益增长，这促使人们对采用纳米材料开发电化学传感器进行了大量研究。这些材料被定义为至少有一个尺寸在 1 到 100 纳米之间的功能材料，包括金属纳米颗粒、聚合物、碳基纳米复合材料和纳米生物探针。这些传感器具有灵敏度高、选择性强的特点，在同时检测和全面分析单一样品中的多种药物复合物方面发挥着重要作用。这篇综述全面探讨了基于纳米材料的电化学传感器的设计、制造和应用，重点关注它们实现多种药用物质多重检测的能力。文中还讨论了为提高传感器性能而采用的策略和纳米材料。此外，该综述还探讨了这一不断发展的领域所面临的挑战和未来前景，强调了基于纳米材料的电化学传感器对医药检测技术进步的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.