Rodents as reservoir hosts in the transmission of Schistosoma mansoni in Richard-Toll, Senegal, West Africa

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-12 DOI:10.1017/s0022149x00700794

J.M. Duplantier, M. Sène

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Abstract

More than 2000 animals belonging to six different rodent species and one insectivore species were examined for infection with schistosomes in the region of Richard-Toll, Senegal. Two murid rodents, Arvicanthisniloticus and Mastomyshuberti, were found infected with Schistosomamansoni. Prevalences were about 5% for both rodent species with a mean worm burden of about 20 worms per host. The sex-ratios of S.mansoni worms were always biased towards males. Prevalences and worm burdens, although similar in both male and female rodents, increased significantly with age. The highest prevalences and worm burdens were found near habitations and decreased significantly with the distance from the town of Richard-Toll. Eggs were also observed in the liver and faeces of the two naturally infected rodent species. The results suggest that rodents participate in the transmission of intestinal schistosomiasis in Richard-Toll but the human population is the main source of infection. The genetic resemblance between human and murine isolates of S. mansoni suggests that further epidemiological studies are needed in this region of Senegal.

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啮齿动物是西非塞内加尔理查德-托尔地区曼氏血吸虫传播的蓄积宿主

对塞内加尔理查德-托尔地区的六种不同啮齿动物和一种食虫动物的 2000 多只动物进行了血吸虫感染检查。发现两种鼠科啮齿动物（Arvicanthisniloticus和Mastomyshuberti）感染了血吸虫。这两种啮齿类动物的感染率约为 5%，平均每只宿主携带约 20 个蠕虫。曼氏血吸虫的性别比例总是偏向雄性。虽然雌雄啮齿类动物的感染率和虫体负荷相似，但随着年龄的增长，感染率和虫体负荷显著增加。啮齿动物栖息地附近的感染率和蠕虫量最高，随着与理查德-托尔镇距离的增加，感染率和蠕虫量明显下降。在两种自然感染的啮齿动物的肝脏和粪便中也发现了虫卵。结果表明，啮齿类动物参与了理查德-托尔镇的肠血吸虫病传播，但人类才是主要的感染源。曼氏血吸虫人鼠分离株之间的遗传相似性表明，需要在塞内加尔的这一地区开展进一步的流行病学研究。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.