Enhanced Cytotoxic Efficacy of Ocimum basilicum Leaf Extract-Mediated TiO2 Nanocrystals

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Cluster Science Pub Date : 2024-04-07 DOI:10.1007/s10876-024-02603-2

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引用次数: 0

Abstract

Breast cancer has become a global health burden, and therefore requires necessitating action against the development of affordable, target-oriented, and safe chemotherapeutic agents to mitigate its prevalence worldwide. In the present report, titanium oxide (TiO₂) nanocrystals (NCs) were synthesized using the green route utilizing Ocimum basilicum leaf extract (OBLE). X-ray diffraction (XRD) studies revealed that TiO₂ NCs exhibit tetragonal crystal configuration with anatase-type symmetry with \(I{4}_{1/}amd\) space group. The phenolic groups (–OH) present in OBLE were detected as the bend appeared at 3420 cm^− 1 in the infrared spectrum. The characteristic hump positioned at 331 nm in the UV–visible diffuse reflectance spectrum (UV–DRS) of biosynthesized TiO₂ NCs confirmed the formation of nanoparticles and the optical band gap of TiO₂ NCs was found to be 3.41 eV as evaluated from Tauc’s plot. The surface morphology of TiO₂ NCs showed minute agglomeration with an average particle size of 11.8 ± 0.66 nm as obtained from statistical analysis of the particle size distribution. The cytotoxic activity of TiO₂ NCs was investigated against MDA–MB 231 cancer cells and dose-dependent cell inhibition was observed with a low IC₅₀ value of 13.35 µg/mL after 48 h of incubation time. The present study underscores the remarkable cytotoxicity demonstrated by TiO₂ NCs against breast cancer cell lines.

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提高金盏花叶提取物介导的二氧化钛纳米晶体的细胞毒性功效

摘要乳腺癌已成为全球性的健康负担，因此有必要开发经济实惠、靶向性强且安全的化疗药物，以降低其在全球的发病率。本报告利用绿萝叶提取物（OBLE）通过绿色途径合成了氧化钛（TiO2）纳米晶体（NCs）。X 射线衍射（XRD）研究表明，TiO2 NCs 呈锐钛矿型对称的四方晶体构型，具有 \(I{4}_{1/}amd\) 空间群。在红外光谱中，OBLE 中的酚基（-OH）在 3420 cm- 1 处出现弯曲。在生物合成的 TiO2 NCs 的紫外可见光漫反射光谱（UV-DRS）中，位于 331 纳米处的特征驼峰证实了纳米颗粒的形成，根据陶氏图的评估，TiO2 NCs 的光带隙为 3.41 eV。根据粒度分布统计分析，TiO2 NCs 的表面形态显示出微小的团聚，平均粒度为 11.8 ± 0.66 nm。研究还考察了 TiO2 NCs 对 MDA-MB 231 癌细胞的细胞毒性活性，结果表明，在培养 48 小时后，TiO2 NCs 对细胞的抑制作用呈剂量依赖性，IC50 值低至 13.35 µg/mL。本研究强调了二氧化钛 NCs 对乳腺癌细胞株的显著细胞毒性。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.