Polymers and their engineered analogues for ocular drug delivery: Enhancing therapeutic precision

IF 3.2 4区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biopolymers Pub Date : 2024-04-05 DOI:10.1002/bip.23578

Arpon Biswas, Shivansh Kumar, Abhijit Deb Choudhury, Amol Chhatrapati Bisen, Sachin Nashik Sanap, Sristi Agrawal, Anjali Mishra, Sarvesh Kumar Verma, Mukesh Kumar, Rabi Sankar Bhatta

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引用次数: 0

Abstract

Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan, and gelatin, alongside synthetic counterparts such as PLGA and PEG, have gained prominence for their biocompatibility and controlled release profiles. Recent strides in polymer conjugation strategies have enabled targeted delivery through ligand integration, facilitating tissue specificity and cellular uptake. This versatility accommodates combined drug delivery, addressing diverse anterior (e.g., glaucoma, dry eye) and posterior segment (e.g., macular degeneration, diabetic retinopathy) afflictions. The review encompasses an in-depth exploration of each natural and synthetic polymer, detailing their individual advantages and disadvantages for ocular drug delivery. By transcending ocular barriers and refining therapeutic precision, these innovations promise to reshape the management of anterior and posterior segment eye diseases.

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用于眼部给药的聚合物及其工程类似物：提高治疗精度

眼部给药受到解剖和生理障碍的限制，因此需要创新的解决方案来实现有效治疗。透明质酸、壳聚糖和明胶等天然聚合物以及聚乳酸（PLGA）和聚乙二醇（PEG）等合成聚合物因其生物相容性和控释特性而备受瞩目。近年来，聚合物共轭策略取得了长足进步，通过配体整合实现了靶向给药，促进了组织特异性和细胞吸收。这种多功能性可用于联合给药，解决各种前段（如青光眼、干眼症）和后段（如黄斑变性、糖尿病视网膜病变）问题。这篇综述深入探讨了每种天然和合成聚合物，详细介绍了它们在眼部给药方面的各自优缺点。通过跨越眼部障碍和提高治疗精度，这些创新有望重塑前后节眼病的治疗方法。

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来源期刊

Biopolymers 生物-生化与分子生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Founded in 1963, Biopolymers publishes strictly peer-reviewed papers examining naturally occurring and synthetic biological macromolecules. By including experimental and theoretical studies on the fundamental behaviour as well as applications of biopolymers, the journal serves the interdisciplinary biochemical, biophysical, biomaterials and biomedical research communities.