Acquired resistance in rainbow trout against Gyrodactylus derjavini

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-12 DOI:10.1017/s0022149x00700836

T. Lindenstrøm, K. Buchmann

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Abstract

Investigations were conducted on the host response in rainbow trout and the associated changes in mucous cell density during infection with the skin monogenean Gyrodactylus derjavini. Parasite populations increased on all naive hosts and peaked 4–5 weeks p.i. after which infection levels decreased. Introduction of naive fish into responding host populations resulted in heavy infections of the naive fish, whereas parasite expulsion continued in the responding host groups showing an acquired, non-sterile immunity. This non-sterile immunity lasted at least a month as these hosts were refractory to reinfection despite being exposed to a high infection pressure. Mucous cell hyperplasia was seen in some groups during the intermediary phase of infection, but at the termination of the study a significant depletion was evident. Passive immunization of naive host (with sera from immune hosts) did not confer protection. This indicates differences between host responses to G. derjavini compared to responses against other pathogens where such a passive immunity has been described.

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虹鳟鱼获得的对河豚的抗药性

研究人员对虹鳟的宿主反应以及在感染皮肤单线虫 Gyrodactylus derjavini 期间粘液细胞密度的相关变化进行了调查。寄生虫数量在所有天真宿主身上都有所增加，并在4-5周后达到高峰，之后感染水平下降。将幼稚鱼引入有反应的宿主群体会导致幼稚鱼受到严重感染，而有反应的宿主群体则会继续驱除寄生虫，显示出获得性非无菌免疫力。这种非无菌免疫至少持续了一个月，因为这些宿主尽管暴露在高感染压力下，但对再感染仍有抵抗力。在感染的中间阶段，一些组出现了粘液细胞增生，但在研究结束时，粘液细胞明显减少。对天真的宿主进行被动免疫（使用免疫宿主的血清）并不能产生保护作用。这表明宿主对 G. derjavini 的反应不同于对其他病原体的反应，在其他病原体中也曾出现过这种被动免疫。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.