N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide endosomal coat complex formation

Abstract

• The assembly of BAR domain-containing endosomal coats such as retromer involves BAR-BAR pairing, though recent work suggests that additional structural features contribute to subunit selection

• We identified features in the unstructured N-termini of two paralogous yeast SNX-BARs, Vps5 and Vin1, that mediate the specific formation of the related retromer and VINE complexes

• Our findings highlight how disordered regions in SNX-BARs help determine the composition of sorting complexes, thereby clarifying mechanisms of modular membrane coat assembly