Genetic variations in CYP2A6, CYP2E1, GSTM1, GSTT1 genes and the risk of Nasopharyngeal carcinoma in North African population

IF 1 4区生物学 Q4 GENETICS & HEREDITY

Annals of Human Genetics Pub Date : 2024-04-15 DOI:10.1111/ahg.12562

Imane EL Alami, Wafa Khaali, Majida Jalbout, Amina Gihbid, Wided Ben Ayoub, Abdellatif Benider, Selma Mohamed Brahim, Mokhtar Hamdi Cherif, Nadia Benchakroun, Mohammed El Mzibri, El Khalil Ben Driss, Khalid Belghmi, Marilys Corbex, Meriem Khyatti

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引用次数: 0

Abstract

Background

Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy associated with both genetic and environmental factors. Polymorphic deletions of the phase I and phase II genes involved in the detoxification of potential carcinogens may be a risk factor for nasopharyngeal carcinoma. In this study, we investigated the relationship between CYP2E1 (rs3813867), CYP2A6, GSTM1(rs1183423000) and GSTT1(rs1601993659) gene variations and NPC risk in North African countries with the highest incidence of NPC (Morocco, Algeria and Tunisia). and the evaluation of the potential use of these variants as potential biomarkers for NPC management.

Methods

A total of 600 NPC cases and 545 controls frequency-matched on ethnicity, sex, age and childhood household type, were recruited from three North African countries (Morocco, Algeria and Tunisia) and analysed. Genotyping of CYP2A6 and CYP2E1(rs3813867) was performed by polymerase chain reaction restriction (PCR)-fragment length polymorphism (RFLP) analysis and the GSTM1 (rs1183423000) and GSTT1(rs1601993659) genetic variations were evaluated using the PCR technique.

Results

The genotype distributions of CYP2E1(rs3813867), CYP2A6, GSTM1(rs1183423000) and GSTT1(rs1601993659) genotypes did not differ significantly among NPC cases and controls (p > 0.05). Furthermore, our data did not reveal any association with smoking and the studied variants, even when the samples were stratified by the duration period of smoking.

Conclusion

In this large studied North African population, our findings suggest that the functional CYP2E1, CYP2A6, GSTM1 and GSTT1 variations did not influence NPC susceptibility.

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北非人群中 CYP2A6、CYP2E1、GSTM1 和 GSTT1 基因的遗传变异与鼻咽癌的患病风险

鼻咽癌是一种与遗传和环境因素相关的多因素恶性肿瘤。参与潜在致癌物解毒的 I 期和 II 期基因的多态性缺失可能是鼻咽癌的一个风险因素。在这项研究中，我们在鼻咽癌发病率最高的北非国家（摩洛哥、阿尔及利亚和突尼斯）调查了 CYP2E1 (rs3813867)、CYP2A6、GSTM1(rs1183423000) 和 GSTT1(rs1601993659) 基因变异与鼻咽癌风险之间的关系，并评估了将这些变异作为鼻咽癌管理的潜在生物标志物的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Genetics 生物-遗传学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Annals of Human Genetics publishes material directly concerned with human genetics or the application of scientific principles and techniques to any aspect of human inheritance. Papers that describe work on other species that may be relevant to human genetics will also be considered. Mathematical models should include examples of application to data where possible. Authors are welcome to submit Supporting Information, such as data sets or additional figures or tables, that will not be published in the print edition of the journal, but which will be viewable via the online edition and stored on the website.