The role of mesenchymal stem cells in early programming of adipose tissue in the offspring of women with obesity

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-04-08 DOI:10.1111/ijpo.13120

Sofía Bellalta, Torsten Plösch, Marijke Faas, Paola Casanello

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Abstract

Maternal obesity is a well-known risk factor for developing premature obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes in the progeny. The development of white adipose tissue is a dynamic process that starts during prenatal life: fat depots laid down in utero are associated with the proportion of fat in children later on. How early this programming takes place is still unknown. However, recent evidence shows that mesenchymal stem cells (MSC), the embryonic adipocyte precursor cells, show signatures of the early setting of an adipogenic committed phenotype when exposed to maternal obesity. This review aims to present current findings on the cellular adaptations of MSCs from the offspring of women with obesity and how the metabolic environment of MSCs could affect the early commitment towards adipocytes. In conclusion, maternal obesity can induce early programming of fetal adipose tissue by conditioning MSCs. These cells have higher expression of adipogenic markers, altered insulin signalling and mitochondrial performance, compared to MSCs of neonates from lean pregnancies. Fetal MSCs imprinting by maternal obesity could help explain the increased risk of childhood obesity and development of further noncommunicable diseases.

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间充质干细胞在肥胖妇女后代脂肪组织早期编程中的作用

摘要母体肥胖是导致后代过早肥胖、代谢综合征、心血管疾病和 2 型糖尿病的一个众所周知的风险因素。白色脂肪组织的发育是一个动态过程，在产前就已经开始：在子宫内形成的脂肪储层与日后孩子的脂肪比例有关。目前还不清楚这一过程发生的时间。不过，最近的证据显示，间充质干细胞（MSC）作为胚胎脂肪细胞的前体细胞，在暴露于母体肥胖的情况下，显示出脂肪生成表型的早期设置特征。本综述旨在介绍目前关于肥胖妇女后代间充质干细胞的细胞适应性研究结果，以及间充质干细胞的代谢环境如何影响其早期向脂肪细胞的承诺。总之，母体肥胖可通过调节间充质干细胞诱导胎儿脂肪组织的早期编程。与瘦孕妇的间充质干细胞相比，这些细胞具有更高的脂肪形成标志物表达、胰岛素信号改变和线粒体性能。母体肥胖对胎儿间充质干细胞的影响可能有助于解释儿童肥胖风险增加和进一步发展为非传染性疾病的原因。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.