Effects of arsenic exposure on blood trace element levels in rats and sex differences

IF 4.1 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biometals Pub Date : 2024-04-03 DOI:10.1007/s10534-024-00594-1

Xiaoqian Ran, Xi Yan, Hongbin Zhuang, Zhiyuan Liang, Guanwei Ma, Xiaolu Chen, Yuhan Huang, Xukun Liu, Peng Luo, Ting Hu, Jun Zhang, Liming Shen

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Abstract

Arsenic (As) is a widespread environmental metalloid and human carcinogen, and its exposure is associated with a wide range of toxic effects, leading to serious health hazards. As poisoning is a complex systemic multi-organ and multi-system damage disease. In this study, a rat model of As poisoning was established to investigate the levels of trace elements in the blood of rats and sex differences in the effect of As on every trace elements in rat blood. Twenty 6-week-old SD (Sprague Dawley) rats were randomly divided into the control group and the As-exposed group. After 3 months, the contents of 19 elements including As in the blood were detected in these two groups by inductively coupled plasma mass spectrometry (ICP-MS). As levels in the blood of As-exposed rats were significantly higher than those in the control group, with increased levels of Rb, Sr, Cs and Ce, and decreased levels of Pd. As showed a significant positive correlation with Rb. There were significant sex differences in blood Se, Pd, Eu, Dy, Ho, and Au levels in the As-exposed group. The results showed that As exposure can lead to an increase of As content in blood and an imbalance of some elements. There were sex differences in the concentration and the correlation between elements of some elements. Elemental imbalances may affect the toxic effects of As and play a synergistic or antagonistic role in As toxicity.

Graphical abstract

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砷暴露对大鼠血液微量元素水平的影响及性别差异

砷（As）是一种广泛存在于环境中的类金属，也是人类的致癌物质，接触砷会产生广泛的毒性效应，导致严重的健康危害。砷中毒是一种复杂的全身性多器官、多系统损害疾病。本研究建立了大鼠砷中毒模型，以探讨大鼠血液中微量元素的含量以及砷对大鼠血液中各种微量元素影响的性别差异。将 20 只 6 周大的 SD（Sprague Dawley）大鼠随机分为对照组和砷暴露组。3 个月后，用电感耦合等离子体质谱法（ICP-MS）检测两组大鼠血液中包括 As 在内的 19 种元素的含量。接触砷的大鼠血液中砷的含量明显高于对照组，同时铷、锶、铯和钴的含量也有所增加，而钯的含量则有所下降。As 与 Rb 呈明显的正相关。砷暴露组的血液中 Se、Pd、Eu、Dy、Ho 和 Au 含量存在明显的性别差异。结果表明，接触砷会导致血液中砷含量的增加和某些元素的失衡。某些元素的浓度和元素之间的相关性存在性别差异。元素失衡可能会影响砷的毒性效应，并在砷毒性中发挥协同或拮抗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biometals 生物-生化与分子生物学

CiteScore

5.90

自引率

8.60%

发文量

111

审稿时长

3 months

期刊介绍： BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.

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