Aberrant Brain Triple-Network Effective Connectivity Patterns in Type 2 Diabetes Mellitus

IF 3.8 3区 医学 Q2 Medicine
Yujie Zhang, Xiao Yin, Yu-Chen Chen, Huiyou Chen, Mingxu Jin, Yuehu Ma, Wei Yong, Vijaya Prakash Krishnan Muthaiah, Wenqing Xia, Xindao Yin
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Abstract

Introduction

Aberrant brain functional connectivity network is thought to be related to cognitive impairment in patients with type 2 diabetes mellitus (T2DM). This study aims to investigate the triple-network effective connectivity patterns in patients with T2DM within and between the default mode network (DMN), salience network (SN), and executive control network (ECN) and their associations with cognitive declines.

Methods

In total, 92 patients with T2DM and 98 matched healthy controls (HCs) were recruited and underwent resting-state functional magnetic resonance imaging (rs-fMRI). Spectral dynamic causal modeling (spDCM) was used for effective connectivity analysis within the triple network. The posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), lateral prefrontal cortex (LPFC), supramarginal gyrus (SMG), and anterior insula (AINS) were selected as the regions of interest. Group comparisons were performed for effective connectivity calculated using the fully connected model, and the relationships between effective connectivity alterations and cognitive impairment as well as clinical parameters were detected.

Results

Compared to HCs, patients with T2DM exhibited increased or decreased effective connectivity patterns within the triple network. Furthermore, diabetes duration was significantly negatively correlated with increased effective connectivity from the r-LPFC to the mPFC, while body mass index (BMI) was significantly positively correlated with increased effective connectivity from the l-LPFC to the l-AINS (r = − 0.353, p = 0.001; r = 0.377, p = 0.004).

Conclusion

These results indicate abnormal effective connectivity patterns within the triple network model in patients with T2DM and provide new insight into the neurological mechanisms of T2DM and related cognitive dysfunction.

2 型糖尿病患者大脑三重网络有效连接模式异常
导言:人们认为,异常的大脑功能连接网络与2型糖尿病(T2DM)患者的认知障碍有关。本研究旨在调查 T2DM 患者默认模式网络(DMN)、显著性网络(SN)和执行控制网络(ECN)内部和之间的三重网络有效连接模式及其与认知能力下降的关系。方法共招募了 92 名 T2DM 患者和 98 名匹配的健康对照组(HCs),并对他们进行了静息态功能磁共振成像(rs-fMRI)检查。光谱动态因果建模(spDCM)用于分析三重网络内的有效连通性。研究人员选择了后扣带回皮层(PCC)、内侧前额叶皮层(mPFC)、外侧前额叶皮层(LPFC)、上边缘回(SMG)和前岛叶(AINS)作为研究区域。结果与普通人相比,T2DM患者在三重网络中表现出有效连接模式的增加或减少。此外,糖尿病持续时间与从 r-LPFC 到 mPFC 的有效连接性增加呈显著负相关,而体重指数(BMI)与从 l-LPFC 到 l-AINS 的有效连接性增加呈显著正相关(r = - 0.结论这些结果表明 T2DM 患者的三重网络模型中存在异常的有效连接模式,并为 T2DM 及相关认知功能障碍的神经机制提供了新的视角。
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来源期刊
Diabetes Therapy
Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
6.90
自引率
7.90%
发文量
130
审稿时长
6 weeks
期刊介绍: Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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