Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi

IF 2 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Vishal Sharma, Shivali Panjgotra, Nisha Sharma, Vidushi Abrol, Umesh Goutam, Sundeep Jaglan
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引用次数: 0

Abstract

Scientists are making efforts to search for new metabolites as they are essential lead molecules for the drug discovery, much required due to the evolution of multi drug resistance and new diseases. Moreover, higher production of known drugs is required because of the ever growing population. Microorganisms offer a vast collection of chemically distinct compounds that exhibit various biological functions. They play a crucial role in safeguarding crops, agriculture, and combating several infectious ailments and cancer. Research on fungi have grabbed a lot of attention after the discovery of penicillin, most of the compounds produced by fungi under normal cultivation conditions are discovered and now rarely new compounds are discovered. Treatment of fungi with the epigenetic modifiers has been becoming very popular since the last few years to boost the discovery of new molecules and enhance the production of already known molecules. Epigenetic literally means above genetics that actually does not alter the genome but alter its expression by altering the state of chromatin from heterochromatin to euchromatin. Chromatin in heterochromatin state usually doesn’t express because it is closely packed by histones in this state. Epigenetic modifiers loosen the packing of chromatin by inhibiting DNA methylation and histone deacetylation and thus permit the expression of genes that usually remain dormant. This study delves into the possibility of utilizing epigenetic modifying agents to generate pharmacologically significant secondary metabolites from fungi.

Abstract Image

表观遗传修饰剂作为真菌中生物活性次生代谢物的诱导剂
科学家们正在努力寻找新的代谢物,因为它们是药物发现所必需的先导分子。此外,由于人口不断增长,需要提高已知药物的产量。微生物提供了大量化学性质不同的化合物,具有各种生物功能。它们在保护农作物、农业、防治多种传染性疾病和癌症方面发挥着至关重要的作用。青霉素发现后,对真菌的研究引起了广泛关注,真菌在正常培养条件下产生的大部分化合物都已被发现,现在很少有新化合物被发现。近几年来,用表观遗传修饰剂处理真菌变得非常流行,以促进新分子的发现和提高已知分子的产量。表观遗传的字面意思是在遗传学之上,实际上并不改变基因组,而是通过改变染色质从异染色质到染色质的状态来改变基因组的表达。处于异染色质状态的染色质通常不会表达,因为在这种状态下,染色质被组蛋白紧密包裹。表观遗传修饰剂通过抑制DNA甲基化和组蛋白去乙酰化来松动染色质的包装,从而使通常处于休眠状态的基因得以表达。本研究探讨了利用表观遗传修饰剂从真菌中产生具有药理学意义的次级代谢产物的可能性。
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来源期刊
Biotechnology Letters
Biotechnology Letters 工程技术-生物工程与应用微生物
CiteScore
5.90
自引率
3.70%
发文量
108
审稿时长
1.2 months
期刊介绍: Biotechnology Letters is the world’s leading rapid-publication primary journal dedicated to biotechnology as a whole – that is to topics relating to actual or potential applications of biological reactions affected by microbial, plant or animal cells and biocatalysts derived from them. All relevant aspects of molecular biology, genetics and cell biochemistry, of process and reactor design, of pre- and post-treatment steps, and of manufacturing or service operations are therefore included. Contributions from industrial and academic laboratories are equally welcome. We also welcome contributions covering biotechnological aspects of regenerative medicine and biomaterials and also cancer biotechnology. Criteria for the acceptance of papers relate to our aim of publishing useful and informative results that will be of value to other workers in related fields. The emphasis is very much on novelty and immediacy in order to justify rapid publication of authors’ results. It should be noted, however, that we do not normally publish papers (but this is not absolute) that deal with unidentified consortia of microorganisms (e.g. as in activated sludge) as these results may not be easily reproducible in other laboratories. Papers describing the isolation and identification of microorganisms are not regarded as appropriate but such information can be appended as supporting information to a paper. Papers dealing with simple process development are usually considered to lack sufficient novelty or interest to warrant publication.
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