Mutations in the leptin-melanocortin pathway and weight loss after bariatric surgery: a systematic review and meta-analysis

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-04-05 DOI:10.1002/oby.24007

Nianrong Zhang, Hao Wang, Shuman Ran, Zhe Wang, Biao Zhou, Siqi Wang, Zhengqi Li, Baoyin Liu, Yuntao Nie, Yishan Huang, Hua Meng

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引用次数: 0

Abstract

Objective

The objective of this meta-analysis was to quantify the overall effects of gene mutations in the leptin-melanocortin pathway on short- and long-term weight loss after bariatric surgery.

Methods

MEDLINE, PubMed, and Embase were searched, and data were analyzed using ReviewManager (RevMan) version 5.4. The datasets were divided into two subgroups based on postoperative time, and the outcome measure was the percentage of total weight loss. Meta-regression analysis was performed, and the outcome was presented as the weighed mean difference of percentage of total weight loss.

Results

The results showed that patients with mutations in the leptin-melanocortin pathway experienced 3.03% lower total weight loss after bariatric surgery (mean difference, −3.03; 95% CI: −3.63 to −2.44), mainly reflected in lower long-term postoperative weight loss (mean difference, −3.43; 95% CI: −4.09 to −2.77), whereas mutation carriers exhibited a magnitude of short-term postoperative weight loss that was similar to patients without such mutations (total difference value, −1.13; 95% CI: −2.57 to 0.31).

Conclusions

Mutations in leptin-melanocortin pathway genes reduce long-term weight loss after bariatric surgery, whereas this effect may not be reflected during the period of rapid weight loss within 12 months. These genetic variants increase the difficulties in maintaining patients' long-term weight loss.

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瘦素-黑色素皮质素通路中的突变与减肥手术后的体重减轻：系统回顾和荟萃分析

方法检索MEDLINE、PubMed和Embase，并使用ReviewManager（RevMan）5.4版分析数据。根据术后时间将数据集分为两个亚组，结果指标为总重量减少的百分比。结果显示，瘦素-黑皮素通路突变的患者在减肥手术后的总体重减轻率降低了3.03%（平均差异为-3.03；95% CI：-3.63至-2.44），主要体现在术后长期体重减轻率较低（平均差异为-3.结论瘦素-黑色素皮质素通路基因的变异会减少减肥手术后的长期体重减轻，而这种影响在 12 个月内体重快速下降期间可能无法体现。这些基因变异增加了患者维持长期体重减轻的难度。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.