Exploring the stability of single emulsion created by microfluidics and its use in the production of core–shell microparticles

IF 2.3 4区工程技术 Q2 INSTRUMENTS & INSTRUMENTATION

Microfluidics and Nanofluidics Pub Date : 2024-04-08 DOI:10.1007/s10404-024-02723-1

Mehrnaz Oveysi, Vahid Bazargan, Amir Nejat, Marco Marengo

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Abstract

This study introduces an innovative method aimed at achieving exceptional stability in emulsions. The primary focus is on re-emulsifying precisely controlled and uniform initial single emulsions, generated by microfluidic devices, to produce single-core double emulsions and core–shell microparticles. Departing from traditional approaches, our method employs a unique combination of advanced Two-level fractional factorial design and numerical simulation. These tools are utilized to discern and optimize critical parameters necessary for the formation of highly monodispersed stable single emulsions and their subsequent transformation into double emulsions. Correlations are established to estimate the size and stability of the primary single emulsion based on immiscible phase flow rate ratio and surfactant concentration. These correlations provide a comprehensive understanding that facilitates the intentional development of desired water-in-oil emulsions. The proposed microfluidic paradigm shows promise for the controlled and efficient production of single-core double emulsions, with broad applications in Pharmaceuticals, Food, and Cosmetics.

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探索微流控技术产生的单一乳液的稳定性及其在核壳微颗粒生产中的应用

本研究介绍了一种创新方法，旨在实现乳液的卓越稳定性。主要重点是对微流控装置产生的精确控制和均匀的初始单乳液进行再乳化，以产生单核双乳液和核壳微粒。与传统方法不同，我们的方法采用了先进的两级分因子设计和数值模拟的独特组合。利用这些工具来识别和优化形成高度单分散稳定的单乳液以及随后转化为双乳液所需的关键参数。根据不相溶相流率比和表面活性剂浓度建立相关关系，以估计初级单乳液的大小和稳定性。这些相关性提供了一种全面的理解，有助于有意识地开发所需的油包水乳液。所提出的微流体范例有望实现单核双乳液的可控高效生产，在制药、食品和化妆品领域有着广泛的应用。

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来源期刊

Microfluidics and Nanofluidics 工程技术-纳米科技

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

2 months

期刊介绍： Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).