Erturan Yetiskin, Sinan Gucluer, Ilayda Erdem, Adem Ozcelik
{"title":"A 3D printed acoustofluidic nozzle-diffuser microfluidic pump","authors":"Erturan Yetiskin, Sinan Gucluer, Ilayda Erdem, Adem Ozcelik","doi":"10.1007/s10404-024-02722-2","DOIUrl":null,"url":null,"abstract":"<div><p>Microfluidic flow control systems are critical components for on-chip biomedical applications. This study introduces a new micropump for on-chip sample preparation and analysis by using an acoustic nozzle diffuser mechanism. The micropump implements a commercially available transducer and control board kit with 3D-printed fluid reservoirs. In this micropump, conic-shaped micro-holes on the metal sheet cover of the transducer are employed as oscillating nozzle diffuser micro arrays to achieve directional flow control. The micropump is shown to efficiently pump water and particle mixtures exceeding flow rates of 515 µl/min at a 12-volt input voltage. In addition, owing to the small size of the nozzle hole opening, larger particles can also be filtered out from a sample solution during fluid pumping enabling a new function. Importantly, the micropump can be fabricated and assembled without needing a cleanroom, making it more accessible. This feature is advantageous for researchers and practitioners, eliminating a significant barrier to entry. By combining commercially available components with 3D printing technology, this micropump presents a cost-effective and versatile solution for on-chip applications in biomedical research and analysis.</p></div>","PeriodicalId":706,"journal":{"name":"Microfluidics and Nanofluidics","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10404-024-02722-2.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microfluidics and Nanofluidics","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10404-024-02722-2","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
引用次数: 0
Abstract
Microfluidic flow control systems are critical components for on-chip biomedical applications. This study introduces a new micropump for on-chip sample preparation and analysis by using an acoustic nozzle diffuser mechanism. The micropump implements a commercially available transducer and control board kit with 3D-printed fluid reservoirs. In this micropump, conic-shaped micro-holes on the metal sheet cover of the transducer are employed as oscillating nozzle diffuser micro arrays to achieve directional flow control. The micropump is shown to efficiently pump water and particle mixtures exceeding flow rates of 515 µl/min at a 12-volt input voltage. In addition, owing to the small size of the nozzle hole opening, larger particles can also be filtered out from a sample solution during fluid pumping enabling a new function. Importantly, the micropump can be fabricated and assembled without needing a cleanroom, making it more accessible. This feature is advantageous for researchers and practitioners, eliminating a significant barrier to entry. By combining commercially available components with 3D printing technology, this micropump presents a cost-effective and versatile solution for on-chip applications in biomedical research and analysis.
微流体流量控制系统是片上生物医学应用的关键部件。本研究采用声学喷嘴扩散器机制,为片上样品制备和分析引入了一种新型微泵。该微型泵采用了市场上可买到的带有 3D 打印储液器的传感器和控制板套件。在该微型泵中,传感器金属板盖上的圆锥形微孔被用作振荡喷嘴扩散器微阵列,以实现定向流量控制。实验表明,在 12 伏输入电压下,该微型泵能有效地泵送水和颗粒混合物,流速超过 515 微升/分钟。此外,由于喷嘴孔开口较小,在泵送流体的过程中还能从样品溶液中过滤出较大的颗粒,实现了一种新的功能。重要的是,这种微型泵无需无尘室即可制造和组装,因此更容易获得。这一特点对于研究人员和从业人员来说非常有利,消除了进入市场的重大障碍。通过将商用元件与 3D 打印技术相结合,该微型泵为生物医学研究和分析领域的片上应用提供了一种经济高效的多功能解决方案。
期刊介绍:
Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include:
1.000 Fundamental principles of micro- and nanoscale phenomena like,
flow, mass transport and reactions
3.000 Theoretical models and numerical simulation with experimental and/or analytical proof
4.000 Novel measurement & characterization technologies
5.000 Devices (actuators and sensors)
6.000 New unit-operations for dedicated microfluidic platforms
7.000 Lab-on-a-Chip applications
8.000 Microfabrication technologies and materials
Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).