Changes in Corneal Epithelial Thickness in Different Areas After Femtosecond Laser–Assisted LASIK in Patients With High Astigmatism

IF 2.9 3区医学 Q1 OPHTHALMOLOGY

Journal of refractive surgery Pub Date : 2024-04-01 DOI:10.3928/1081597x-20240311-04

Anqi Li, MD, Zhichao Liu, MD, Meng Lin, MD, Qianwen Gong, MD, PhD, Linzhi Wei, MD, Fan Lu, MD, OD, Liang Hu, MD, OD

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引用次数: 0

Abstract

Purpose:

To explore changes in corneal epithelial thickness (CET) after femtosecond laser–assisted laser in situ keratomileusis in patients with high astigmatism.

Methods:

CET was measured at every intersection of the concentric circles and specific axes using AngioVue optical coherence tomography (Angio-OCT) preoperatively and 1 month postoperatively. The average thickness of corneal central, paracentral, and peripheral regions was the mean of the points within the central 2, 2 to 5, and 5 to 7 mm areas, respectively. Correlation analysis was performed to investigate the association between CET along different axes and other preoperative and postoperative parameters.

Results:

Forty-two eyes of 28 patients were included. CET along the astigmatic (K1) and perpendicular (K2) axes in the central and paracentral areas increased (P < .001), whereas that along the K2 axis decreased in the peripheral area 1 month postoperatively (P = .001). The amount of CET change in the peripheral area between the K1 and K2 axes was significantly different (P < .001). In the central area, the change in CET along the K2 axis was positively correlated with ablation depth (r = 0.315, P = .042) and negatively with refractive power after surgery (r = −0.347, P = .024). In the peripheral area, the changes in CET along both K1 and K2 axes were negatively correlated with ablation depth (r = −0.431, P = .004; r = −0.387, P = .011, respectively).

Conclusions:

Epithelial modeling differed between the different astigmatism axes after refractive surgery. The compensatory response of the corneal epithelium is more pronounced along the steeper axis.

[J Refract Surg. 2024;40(4):e239–e244.]

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高度散光患者接受飞秒激光辅助 LASIK 手术后不同区域角膜上皮厚度的变化

目的：探讨飞秒激光辅助激光原位角膜磨镶术后高度散光患者角膜上皮厚度（CET）的变化。方法：术前和术后1个月，使用AngioVue光学相干断层扫描（Angio-OCT）测量同心圆和特定轴的每个交点的CET。角膜中央、中央旁和周边区域的平均厚度分别为中央 2 毫米、2 至 5 毫米和 5 至 7 毫米区域内各点的平均值。结果：共纳入了 28 名患者的 42 只眼睛。术后 1 个月，中央区和旁中心区沿散光轴（K1）和垂直轴（K2）的 CET 增加（P < .001），而周边区沿 K2 轴的 CET 减少（P = .001）。外周区域 K1 轴和 K2 轴之间的 CET 变化量存在显著差异（P = .001）。在中心区域，沿 K2 轴的 CET 变化与消融深度呈正相关（r = 0.315，P = .042），与术后屈光力呈负相关（r = -0.347，P = .024）。结论：屈光手术后，不同散光轴的角膜上皮模型不同。角膜上皮的代偿反应在较陡的轴上更为明显。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

$Journal of refractive surgery$

Journal of refractive surgery 医学-外科

CiteScore

5.10

自引率

12.50%

发文量

160

审稿时长

4-8 weeks

期刊介绍： The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.