Triptans in the Acute Migraine Management of Children and Adolescents: An Update

IF 3.2 2区 医学 Q2 CLINICAL NEUROLOGY
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Abstract

Purpose of Review

To summarize recent findings regarding triptan use in the acute treatment of pediatric migraine.

Recent Findings

Prevalence of pediatric migraine is rising. The American Headache Society and American Academy of Neurology updated guidelines to provide evidence-based recommendations for the treatment of acute migraine in youth. In the setting of a dearth of new randomized controlled trials (RCTs), we review current guidelines, triptan use in the emergency department, and an era of secondary analyses.

Summary

Measuring the efficacy of triptans in pediatric migraine has been challenged by high placebo response rates. Secondary analyses, combining data from multiple RCTs, support that triptans are safe and effective in the treatment of migraine. Triptans are a vital tool and the only FDA-approved migraine-specific treatment available in pediatrics. There is a need for further studies and funding support in pediatric headache medicine.

儿童和青少年急性偏头痛治疗中的 Triptans:最新进展
摘要 综述目的 总结有关在急性期治疗小儿偏头痛时使用三苯氧胺的最新研究结果。 最新发现 小儿偏头痛的发病率正在上升。美国头痛学会和美国神经病学会更新了指南,为治疗青少年急性偏头痛提供了循证建议。在缺乏新的随机对照试验(RCT)的情况下,我们回顾了当前的指南、急诊科使用三苯氧胺的情况以及二次分析的时代。 摘要 衡量三苯氧胺对小儿偏头痛的疗效一直受到高安慰剂反应率的挑战。综合多项临床试验数据进行的二次分析表明,三苯氧胺对治疗偏头痛安全有效。三苯氧胺是一种重要的治疗工具,也是目前唯一获得美国食品及药物管理局批准的儿科偏头痛特效治疗药物。儿科头痛医学需要进一步的研究和资金支持。
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来源期刊
Current Pain and Headache Reports
Current Pain and Headache Reports CLINICAL NEUROLOGY-
CiteScore
6.10
自引率
2.70%
发文量
91
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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