Effect of proteinuria at relapse on shear wave velocity assessed using ultrasound elastography in children with idiopathic nephrotic syndrome

IF 1.9 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Tomohiko Nishino, Shinya Tomori, Sayaka Ono, Kazuhiro Takahashi, Masakazu Mimaki
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Abstract

Purpose

Shear wave velocity (SWV) is an ultrasound elastography technique that provides much information for kidney disease assessment. However, the factors that alter SWV are not fully understood; it is unclear whether the variation in SWV seen in proteinuria associated with disease progression is due to tissue or proteinuria. This study investigated the effect of proteinuria on SWV.

Methods

This prospective observational study compared SWV at remission with SWV at relapse in children treated for idiopathic nephrotic syndrome (INS) between April 2020 and December 2023. All relapses without oral steroids during the observation period were measured. SWV at remission was defined as the date closest to relapse during which repeated measurements were taken approximately every 3 months after steroid discontinuation.

Results

Eight patients were treated for INS with a median observation period of 21.9 months (11.8–27.1). Of the 15 relapses, five that met the definition were considered for the study. The median interval between the measurement at relapse and remission was 40 days (11–55). SWV was significantly lower at relapse than remission (2.40 ± 0.20 m/s vs. 2.14 ± 0.15 m/s, P < 0.01).

Conclusions

SWV decreased in the presence of severe proteinuria at relapse compared to the remission measurements. Although more cases need to be studied, the decrease in SWV may reflect the mechanism by which protein leaks into the urine, not just a direct change caused by the presence of proteinuria.

Abstract Image

特发性肾病综合征患儿复发时的蛋白尿对使用超声弹性成像技术评估剪切波速度的影响
目的剪切波速度(SWV)是一种超声弹性成像技术,可为肾脏疾病评估提供大量信息。然而,改变 SWV 的因素尚不完全清楚;蛋白尿与疾病进展相关的 SWV 变化是由组织还是蛋白尿引起的,也不清楚。这项前瞻性观察性研究比较了 2020 年 4 月至 2023 年 12 月期间接受特发性肾病综合征(INS)治疗的儿童缓解时的 SWV 和复发时的 SWV。对观察期间所有未口服类固醇的复发病例进行了测量。缓解期的 SWV 被定义为最接近复发的日期,在此期间,停用类固醇后大约每 3 个月重复测量一次。在 15 例复发患者中,有 5 例符合研究定义。复发和缓解时的中位测量间隔为 40 天(11-55 天)。复发时的 SWV 明显低于缓解时(2.40 ± 0.20 m/s vs. 2.14 ± 0.15 m/s,P < 0.01)。尽管还需要对更多病例进行研究,但SWV的下降可能反映了蛋白质渗入尿液的机制,而不仅仅是蛋白尿引起的直接变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
11.10%
发文量
102
审稿时长
>12 weeks
期刊介绍: The Journal of Medical Ultrasonics is the official journal of the Japan Society of Ultrasonics in Medicine. The main purpose of the journal is to provide forum for the publication of papers documenting recent advances and new developments in the entire field of ultrasound in medicine and biology, encompassing both the medical and the engineering aspects of the science.The journal welcomes original articles, review articles, images, and letters to the editor.The journal also provides state-of-the-art information such as announcements from the boards and the committees of the society.
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