Development of deep eutectic solvent systems and their formulation: Assessment of solubilization potential on poorly water-soluble drugs

IF 1.8 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Brijesh M. Shah, Rachel E. Owyeung, Sameer Sonkusale
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Abstract

Modern strategies to deliver drugs efficiently via less toxic non-aqueous carriers like deep eutectic solvents (DES) has grown tremendously. Herein, we develop several synthetic and natural DES to improve solubility of poorly soluble drug, docetaxel (DTX). Menthol:thymol-based natural DES showed 1500-folds higher solubility for DTX than that in water. FTIR-spectroscopy confirmed reduced crystallinity and stable encapsulation of DTX in DES through formation of hydrogen-bond. DTX-DES was developed further into self-emulsified formulation that upon dilution formed nanostructured globules (< 200 nm) and released 20-folds higher DTX than pure drug thereby highlighting the potential of DES for designing formulations of poorly soluble drugs.

Graphical Abstract

Abstract Image

开发深共晶溶剂系统及其配方:评估水溶性差药物的增溶潜力
通过深共晶溶剂(DES)等毒性较低的非水性载体高效递送药物的现代策略已得到了极大的发展。在此,我们开发了几种合成和天然 DES,以提高溶解性较差的药物多西他赛(DTX)的溶解度。基于薄荷醇:百里酚的天然 DES 对 DTX 的溶解度比在水中的溶解度高出 1500 倍。傅立叶变换红外光谱证实,通过形成氢键,DTX 在 DES 中的结晶度降低,封装稳定。DTX-DES 被进一步开发成自乳化制剂,稀释后形成纳米结构的球状物(< 200 nm),DTX 的释放量比纯药物高 20 倍,从而凸显了 DES 在设计溶解性差的药物制剂方面的潜力。
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来源期刊
MRS Communications
MRS Communications MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
2.60
自引率
10.50%
发文量
166
审稿时长
>12 weeks
期刊介绍: MRS Communications is a full-color, high-impact journal focused on rapid publication of completed research with broad appeal to the materials community. MRS Communications offers a rapid but rigorous peer-review process and time to publication. Leveraging its access to the far-reaching technical expertise of MRS members and leading materials researchers from around the world, the journal boasts an experienced and highly respected board of principal editors and reviewers.
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