Therapeutic potential of exosomes in spermatogenesis regulation and male infertility

IF 2.4 4区生物学 Q4 CELL BIOLOGY

Biology of the Cell Pub Date : 2024-04-09 DOI:10.1111/boc.202300127

Amirhossein Mohammadi, Ronak Shabani, Zahra Bashiri, Sara Rafiei, Hamidreza Asgari, Morteza Koruji

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Abstract

Background

Spermatogenesis is a fundamental process crucial for male reproductive health and fertility. Exosomes, small membranous vesicles released by various cell types, have recently garnered attention for their role in intercellular communication.

Objective

This review aims to comprehensively explore the role of exosomes in regulating spermatogenesis, focusing on their involvement in testicular development and cell-to-cell communication.

Methods

A systematic examination of literature was conducted to gather relevant studies elucidating the biogenesis, composition, and functions of exosomes in the context of spermatogenesis.

Results

Exosomes play a pivotal role in orchestrating the complex signaling networks required for proper spermatogenesis. They facilitate the transfer of key regulatory molecules between different cell populations within the testes, including Sertoli cells, Leydig cells, and germ cells.

Conclusion

The emerging understanding of exosome-mediated communication sheds light on novel mechanisms underlying spermatogenesis regulation. Further research in this area holds promise for insights into male reproductive health and potential therapeutic interventions.

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外泌体在精子发生调节和男性不育症中的治疗潜力

背景精子发生是对男性生殖健康和生育能力至关重要的基本过程。本综述旨在全面探讨外泌体在调节精子发生过程中的作用，重点关注外泌体参与睾丸发育和细胞间通讯的情况。结果外泌体在协调正常精子发生所需的复杂信号网络中发挥着关键作用。结果外泌体在协调正常精子发生所需的复杂信号网络中发挥着关键作用。它们促进了睾丸内不同细胞群（包括Sertoli细胞、Leydig细胞和生殖细胞）之间关键调控分子的传递。该领域的进一步研究有望深入了解男性生殖健康和潜在的治疗干预措施。

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来源期刊

Biology of the Cell 生物-细胞生物学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The journal publishes original research articles and reviews on all aspects of cellular, molecular and structural biology, developmental biology, cell physiology and evolution. It will publish articles or reviews contributing to the understanding of the elementary biochemical and biophysical principles of live matter organization from the molecular, cellular and tissues scales and organisms. This includes contributions directed towards understanding biochemical and biophysical mechanisms, structure-function relationships with respect to basic cell and tissue functions, development, development/evolution relationship, morphogenesis, stem cell biology, cell biology of disease, plant cell biology, as well as contributions directed toward understanding integrated processes at the organelles, cell and tissue levels. Contributions using approaches such as high resolution imaging, live imaging, quantitative cell biology and integrated biology; as well as those using innovative genetic and epigenetic technologies, ex-vivo tissue engineering, cellular, tissue and integrated functional analysis, and quantitative biology and modeling to demonstrate original biological principles are encouraged.