Neuroimmunology of Cardiovascular Disease

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reports Pub Date : 2024-04-13 DOI:10.1007/s11906-024-01301-8

Sara M. Zarate, Annet Kirabo, Antentor O. Hinton Jr., Monica M. Santisteban

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Abstract

Purpose of Review

Cardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain’s involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD.

Recent Findings

The brain contains neuroimmune niches comprised of glia in the parenchyma and immune cells at the brain’s borders, and there is strong evidence that these neuroimmune niches are important in both health and disease. Mechanistic studies suggest that the activation of glia and immune cells in these niches modulates CVD progression in hypertension and heart failure and contributes to the inevitable end-organ damage to the brain.

Summary

This review provides evidence supporting the role of neuroimmune niches in CVD progression. However, additional research is needed to understand the effects of prolonged neuroimmune activation on brain function.

Abstract Image

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心血管疾病的神经免疫学

综述目的心血管疾病（CVD）是导致全球死亡和慢性残疾的主要原因。然而，尽管采取了广泛的干预策略，受心血管疾病影响的人数仍在继续增加。因此，人们对揭示可能导致新疗法的新机制非常感兴趣。考虑到这一困境，最近的研究重点转向了心血管疾病病理中的神经免疫机制，从而加深了对大脑参与疾病病理的理解。本综述概述了有关导致心血管疾病的神经免疫机制的新的和突出的发现。最近的发现大脑包含神经免疫龛，由实质中的神经胶质细胞和大脑边界的免疫细胞组成，有强有力的证据表明这些神经免疫龛在健康和疾病中都很重要。机理研究表明，这些龛位中神经胶质细胞和免疫细胞的活化调节了高血压和心力衰竭的心血管疾病进展，并导致了不可避免的大脑终末器官损伤。然而，要了解神经免疫长期激活对大脑功能的影响，还需要进行更多的研究。

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来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.