Autologous platelet concentrate in epiretinal membrane surgery: A single‐centre prospective comparative non‐inferiority study

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2024-04-09 DOI:10.1111/aos.16690

Olga Furashova, Bartlomiej Adrianowicz, Katrin Engelmann

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引用次数: 0

Abstract

PurposeThe purpose of the study was to compare the anatomical and functional results including reading ability after epiretinal membrane (ERM) surgery in patients with and without the use of autologous platelet concentrate (APC).MethodsDesign: Prospective, comparative non‐inferiority series. Setting: Institutional. Patients: 51 eyes of 51 patients, who underwent pars‐plana vitrectomy (PPV) for ERM surgery. 29 eyes additionally received intraoperative APC, 22 eyes underwent standard procedure without APC use. Observations: anatomical and functional outcome parameters (central retinal thickness (CRT), best corrected visual acuity (BCVA) and reading ability (RA)) were compared between the two groups at 6 weeks and 6 months postoperatively. Subjective assessment of visual acuity and reading ability was also analysed. Main outcome measures: BCVA, RA and CRT.ResultsBoth groups showed significant CRT reduction and RA improvement, while BCVA improvement was significant only in eyes with intraoperative APC use during the follow‐up time of 6 months. There was no statistically significant difference between CRT reduction, BCVA and RA improvement between the groups.ConclusionIntraoperative APC use for ERM surgery results in similar anatomical and functional outcomes compared with standard ERM surgery without APC use.

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自体血小板浓缩物在视网膜外膜手术中的应用：单中心前瞻性非劣效性比较研究

研究目的：比较使用和未使用自体血小板浓缩物（APC）的视网膜外膜（ERM）患者手术后的解剖和功能效果，包括阅读能力：前瞻性、对比性非劣效性系列研究。设置：机构。患者：51名患者的51只眼睛接受了玻璃体旁切除术（PPV）以进行ERM手术。其中 29 眼在术中额外接受了 APC，22 眼接受了标准手术，未使用 APC。观察结果：比较了两组患者术后 6 周和 6 个月的解剖和功能结果参数（视网膜中央厚度 (CRT)、最佳矫正视力 (BCVA) 和阅读能力 (RA)）。此外，还对视力和阅读能力的主观评估进行了分析。主要结果指标：结果两组的 CRT 和 RA 均显著降低，而 BCVA 的改善仅在术中使用了 APC 的随访 6 个月期间显著。结论与不使用 APC 的标准 ERM 手术相比，术中使用 APC 的 ERM 手术具有相似的解剖和功能结果。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.