Optimization of RF coil geometry for NMR/MRI applications using a genetic algorithm

IF 2 3区 化学 Q3 BIOCHEMICAL RESEARCH METHODS
Techit Tritrakarn , Masato Takahashi , Tetsuji Okamura
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Abstract

A simulation method that employs a genetic algorithm (GA) for optimizing radio frequency (RF) coil geometry is developed to maximize signal intensity in nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI) applications. NMR/MRI has a wide range of applications, including medical imaging, and chemical and biological analysis to investigate the structure, dynamics, and interactions of molecules. However, NMR suffers from inherently low signal intensity, which depends on factors related to RF coil geometry. The investigation of coil geometry is crucial for improving signal intensity, leading to a reduction in the number of scans and a shorter total scan time. We have explored a better optimization method by modifying RF coil geometry to maximize signal intensity. The RF coil geometry comprises wire elements, each of which is a small vector representing the current flow, and GA chooses some of the prepared wire elements for optimization. The optimization of a substrate coil with a surface perpendicular to a static field was demonstrated for single-sided NMR system applications while considering various cylindrical sample diameters. A non-optimized and a GA-optimized substrate coil were compared through simulation and experiment to confirm the performance of the GA simulation. The maximum error between simulation and experiment was below 5%, with an average of less than 3%, confirming simulation reliability. The results indicated that the GA improved signal intensity by approximately 10% and reduced the necessary total scan time by around 20%. Finally, we explain the limitations and explore other potential applications of this GA-based simulation method.

Abstract Image

利用遗传算法优化 NMR/MRI 应用的射频线圈几何形状
我们开发了一种采用遗传算法(GA)优化射频(RF)线圈几何形状的模拟方法,以最大限度地提高核磁共振(NMR)/磁共振成像(MRI)应用中的信号强度。核磁共振/磁共振成像应用广泛,包括医学成像、化学和生物分析,以研究分子的结构、动力学和相互作用。然而,核磁共振本身存在信号强度低的问题,这取决于与射频线圈几何形状有关的因素。线圈几何形状的研究对于提高信号强度至关重要,可减少扫描次数,缩短总扫描时间。我们探索了一种更好的优化方法,通过修改射频线圈的几何形状来最大限度地提高信号强度。射频线圈的几何形状由线元组成,每个线元都是代表电流流向的小矢量,GA 选择部分准备好的线元进行优化。在考虑各种圆柱形样品直径的情况下,针对单面核磁共振系统的应用,演示了表面垂直于静态场的基底线圈的优化。通过模拟和实验对未优化和经 GA 优化的基底线圈进行了比较,以确认 GA 模拟的性能。模拟和实验之间的最大误差低于 5%,平均误差低于 3%,证实了模拟的可靠性。结果表明,GA 将信号强度提高了约 10%,并将所需的总扫描时间减少了约 20%。最后,我们解释了这种基于 GA 的模拟方法的局限性,并探讨了它的其他潜在应用。
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来源期刊
CiteScore
3.80
自引率
13.60%
发文量
150
审稿时长
69 days
期刊介绍: The Journal of Magnetic Resonance presents original technical and scientific papers in all aspects of magnetic resonance, including nuclear magnetic resonance spectroscopy (NMR) of solids and liquids, electron spin/paramagnetic resonance (EPR), in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS), nuclear quadrupole resonance (NQR) and magnetic resonance phenomena at nearly zero fields or in combination with optics. The Journal''s main aims include deepening the physical principles underlying all these spectroscopies, publishing significant theoretical and experimental results leading to spectral and spatial progress in these areas, and opening new MR-based applications in chemistry, biology and medicine. The Journal also seeks descriptions of novel apparatuses, new experimental protocols, and new procedures of data analysis and interpretation - including computational and quantum-mechanical methods - capable of advancing MR spectroscopy and imaging.
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