Endoplasmic reticulum – condensate interactions in protein synthesis and secretion

IF 6 2区 生物学 Q1 CELL BIOLOGY
Dan T.M. Nguyen , Max Koppers , Ginny G. Farías
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引用次数: 0

Abstract

In the past decade, a growing amount of evidence has demonstrated that organelles do not act autonomously and independently but rather communicate with each other to coordinate different processes for proper cellular function. With a highly extended network throughout the cell, the endoplasmic reticulum (ER) plays a central role in interorganelle communication through membrane contact sites. Here, we highlight recent evidence indicating that the ER also forms contacts with membrane-less organelles. These interactions contribute to the dynamic assembly and disassembly of condensates and controlled protein secretion. Additionally, emerging evidence suggests their involvement in mRNA localization and localized translation. We further explore exciting future directions of this emerging theme in the organelle contact site field.

蛋白质合成和分泌过程中内质网与凝结物的相互作用
在过去的十年中,越来越多的证据表明,细胞器并不是独立自主地行动,而是通过相互交流来协调不同的过程,从而实现正常的细胞功能。内质网(ER)在整个细胞中形成一个高度延伸的网络,通过膜接触点在细胞器间通信中发挥着核心作用。在这里,我们重点介绍最近有证据表明内质网也与无膜细胞器形成接触。这些相互作用有助于凝聚体的动态组装和拆卸以及受控的蛋白质分泌。此外,新出现的证据表明它们参与了 mRNA 定位和定位翻译。我们将进一步探讨细胞器接触位点领域这一新兴主题令人兴奋的未来发展方向。
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来源期刊
Current Opinion in Cell Biology
Current Opinion in Cell Biology 生物-细胞生物学
CiteScore
14.60
自引率
1.30%
发文量
79
审稿时长
93 days
期刊介绍: Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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