Metformin Improves Sarcopenia-Related Quality of Life in Geriatric Adults: A Randomized Controlled Trial

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Rizwan Qaisar , Asima Karim , Tahir Muhammad , M. Shahid Iqbal , Firdos Ahmad
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引用次数: 0

Abstract

Objectives

Metformin protects against age-related muscle decline, termed sarcopenia. However, the effects on sarcopenia quality-of-life (SarQoL) are unknown. We investigated the effects of metformin on SarQoL and associated mechanisms in older adults.

Method

This double-blind randomized, placebo-controlled trial included geriatric adult men, divided into non-sarcopenic controls (age = 72.2 ± 4.3 years, n = 52) and two groups of patients with sarcopenia randomized into placebo (age at baseline = 74.4 ± 5.7 years, n = 54) and metformin (age at baseline = 71.2 ± 3.9 years, n = 47) groups. Patients in the metformin group received 1.7 grams twice daily for four months. We evaluated SarQoL, handgrip strength (HGS), plasma zonulin, c-reactive protein (CRP), and 8-isoprostanes.

Results

Patients with sarcopenia had lower HGS and SarQoL than controls (both p <0.05). Metformin improved the HGS and the SarQoL domains related to physical and mental health, locomotion, and leisure activities, as well as cumulative SarQoL scores (all p <0.05). Metformin also prevented the decline in the SarQoL domains for functionality and fear. Among plasma biomarkers, metformin reduced the levels of zonulin, CRP, 8-isoprostanes, and creatine kinase. We also found a significant correlation of plasma zonulin with cumulative SarQoL in patients with sarcopenia taking metformin, suggesting a role for intestinal repair in improving SarQoL. Finally, metformin did not affect body composition and gait speed.

Conclusion

Overall, metformin improved HGS and SarQoL by repairing intestinal leakage. Our data have clinical relevance for improving the quality of life in older adults with sarcopenia.

二甲双胍可改善老年患者与 "肌肉疏松症 "相关的生活质量:随机对照试验
目的二甲双胍可防止与年龄有关的肌肉衰退,即所谓的 "肌肉疏松症"。然而,二甲双胍对肌肉疏松症患者生活质量(SarQoL)的影响尚不清楚。我们研究了二甲双胍对老年人 SarQoL 的影响及相关机制。方法这项双盲随机安慰剂对照试验纳入了老年成年男性,分为非肌肉疏松症对照组(年龄 = 72.2 ± 4.3 岁,n = 52)和两组肌肉疏松症患者,随机分为安慰剂组(基线年龄 = 74.4 ± 5.7 岁,n = 54)和二甲双胍组(基线年龄 = 71.2 ± 3.9 岁,n = 47)。二甲双胍组患者每天服用两次,每次 1.7 克,连续服用四个月。结果与对照组相比,肌肉疏松症患者的 HGS 和 SarQoL 均较低(均为 p <0.05)。二甲双胍改善了患者的 HGS 和与身心健康、运动和休闲活动相关的 SarQoL 领域,以及 SarQoL 的累积得分(均为 p <0.05)。二甲双胍还能防止SarQoL功能和恐惧领域的下降。在血浆生物标志物中,二甲双胍降低了zonulin、CRP、8-异前列腺素和肌酸激酶的水平。我们还发现,在服用二甲双胍的肌肉疏松症患者中,血浆佐宁与累积 SarQoL 有明显的相关性,这表明肠道修复在改善 SarQoL 方面发挥了作用。结论总体而言,二甲双胍可通过修复肠道渗漏改善 HGS 和 SarQoL。我们的数据对改善患有肌肉疏松症的老年人的生活质量具有临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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