Evidence for grid-cell-like activity in the time domain

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Gregory Peters-Founshtein MD, PhD , Amnon Dafni-Merom MSc , Rotem Monsa MSc , Shahar Arzy MD, PhD
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引用次数: 0

Abstract

The relation between the processing of space and time in the brain has been an enduring cross-disciplinary question. Grid cells have been recognized as a hallmark of the mammalian navigation system, with recent studies attesting to their involvement in the organization of conceptual knowledge in humans. To determine whether grid-cell-like representations support temporal processing, we asked subjects to mentally simulate changes in age and time-of-day, each constituting “trajectory” in an age-day space, while undergoing fMRI. We found that grid-cell-like representations supported trajecting across this age-day space. Furthermore, brain regions concurrently coding past-to-future orientation positively modulated the magnitude of grid-cell-like representation in the left entorhinal cortex. Finally, our findings suggest that temporal processing may be supported by spatially modulated systems, and that innate regularities of abstract domains may interface and alter grid-cell-like representations, similarly to spatial geometry.

Abstract Image

时域中网格细胞样活动的证据
大脑对空间和时间的处理之间的关系一直是一个持久的跨学科问题。网格细胞被认为是哺乳动物导航系统的标志,最近的研究证明它们参与了人类概念知识的组织。为了确定类似网格细胞的表征是否支持时间处理,我们要求受试者在进行fMRI检查的同时,在头脑中模拟年龄和时间的变化,每种变化都构成年龄-时间空间中的 "轨迹"。我们发现,网格-细胞样表征支持在这个年龄-日期空间中的轨迹。此外,同时对过去到未来的方向进行编码的脑区对左侧内侧皮层的网格细胞样表征的幅度有正向调节作用。最后,我们的研究结果表明,时间处理可能会得到空间调节系统的支持,抽象领域的先天规律性可能会与网格细胞样表征相联系并改变网格细胞样表征,这一点与空间几何类似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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