KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides

IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC
Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan
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引用次数: 0

Abstract

A broad scope of quinazolin-4(3H)-ones or benzothiadiazine 1,1-dioxides was obtained via a transition-metal free and convenient method. This approach involving KHSO4 promoted cyclization and dehydration between diverse functionalized 2-aminobenzamides or 2-aminobenzenesulfonamides and N, N-dimethylformamide derivatives. The protocol offers moderate to excellent yields (45%-93%) under mild condition in a short of reaction time of 6 hours. The use of an environment-friendly and less expensive catalyst KHSO4 also makes this protocol more attractive.

KHSO4 促进喹唑啉-4(3H)-酮和苯并噻二嗪 1,1-二氧化物的实用合成
通过一种不含过渡金属的便捷方法,获得了范围广泛的喹唑啉-4(3H)-酮或苯并噻二嗪-1,1-二氧杂环。这种方法涉及 KHSO4,促进了多种官能化 2-氨基苯甲酰胺或 2-氨基苯磺酰胺与 N,N-二甲基甲酰胺衍生物之间的环化和脱水。该方案在温和的条件下,只需 6 小时的反应时间,就能获得中等到极好的产率(45%-93%)。使用环保且价格较低的催化剂 KHSO4 也使该方案更具吸引力。
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来源期刊
Synthetic Communications
Synthetic Communications 化学-有机化学
CiteScore
4.40
自引率
4.80%
发文量
156
审稿时长
4.3 months
期刊介绍: Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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