Application of cefuroxime in the eradication therapy of Helicobacter pylori infection: A review article

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2024-04-11 DOI:10.1111/hel.13073

Changmin Mi, Baojun Suo, Xueli Tian, Yuxin Wang, Lingling Ma, Zhiqiang Song

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引用次数: 0

Abstract

Background

Helicobacter pylori infection and its associated diseases represent a significant global health concern. Patients who cannot use amoxicillin pose a therapeutic challenge and necessitate alternative medications. Preliminary research indicates that cefuroxime demonstrates promising potential for eradicating H. pylori infection, and there is a lack of comprehensive review articles on the use of cefuroxime.

Materials and Methods

This study conducts a thorough systematic literature review and synthesis. A comprehensive systematic search was conducted in PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang Data up to January 13, 2024. The search strategy utilized the following keywords: (Cefuroxime) AND (Helicobacter pylori OR Helicobacter nemestrinae OR Campylobacter pylori OR Campylobacter pylori subsp. pylori OR Campylobacter pyloridis OR H. pylori OR Hp) for both English and Chinese language publications. Sixteen studies from five different countries or regions were included in final literature review.

Results

Analysis results indicate that H. pylori is sensitive to cefuroxime, with resistance rates similar to amoxicillin being relatively low. Regimens containing cefuroxime have shown favorable eradication rates, which were comparable to those of the regimens containing amoxicillin. Regarding safety, the incidence of adverse reactions in cefuroxime-containing eradication regimens was comparable to that of amoxicillin-containing regimens or other bismuth quadruple regimens, with no significant increase in allergic reactions in penicillin-allergic patients. Regarding compliance, studies consistently report high compliance rates for regimens containing cefuroxime.

Conclusion

Cefuroxime can serve as an alternative to amoxicillin for the patients allergic to penicillin with satisfactory efficacies, safety, and compliance.

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头孢呋辛在根除幽门螺旋杆菌感染疗法中的应用：综述文章

背景幽门螺旋杆菌感染及其相关疾病是全球关注的重大健康问题。不能使用阿莫西林的患者给治疗带来了挑战，需要使用替代药物。初步研究表明，头孢呋辛在根除幽门螺杆菌感染方面具有良好的潜力，但目前缺乏关于头孢呋辛使用情况的全面综述文章。材料与方法本研究进行了全面系统的文献综述。截至 2024 年 1 月 13 日，在 PubMed、Web of Science、EMBASE、中国国家知识基础设施、中国生物医学文献数据库和万方数据中进行了全面系统的检索。检索策略使用了以下关键词：（头孢呋辛）和（幽门螺旋杆菌或内膜螺旋杆菌或幽门弯曲杆菌或幽门弯曲杆菌亚种或幽门弯曲杆菌或幽门螺杆菌或Hp），同时检索英文和中文出版物。最终的文献综述包括来自五个不同国家或地区的 16 项研究。结果分析结果表明，幽门螺杆菌对头孢呋辛敏感，耐药率与阿莫西林相似，相对较低。含有头孢呋辛的治疗方案显示出良好的根除率，与含有阿莫西林的治疗方案相当。在安全性方面，含有头孢呋辛的根除方案的不良反应发生率与含有阿莫西林的方案或其他四联铋剂方案相当，青霉素过敏患者的过敏反应没有明显增加。在依从性方面，研究报告一致表明，含有头孢呋辛的治疗方案依从性较高。结论头孢呋辛可作为阿莫西林的替代品，用于对青霉素过敏的患者，其疗效、安全性和依从性均令人满意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.