Nicole A de Weerd , Aleksandra K Kurowska , Juan L Mendoza , Gideon Schreiber
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引用次数: 0
Abstract
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While there are clear similarities in the biological responses toward type I and type III IFNs, differences have been found in their tropism, tuning of activity, and induction of the immune response. Here, we focus on how these differences are embedded in the structure/function relations of these two systems in light of the recent progress that provides in-depth information on the structural assembly of these receptors and their functional implications and how these differ between the mouse and human systems.
I 型和 III 型干扰素（IFNs）是激活先天性免疫反应的主要成分。这两种干扰素共有两条不同的受体链（IFNAR1/IFNAR2 和 IFNLR1/IL10R2），它们在结合各自的配体后形成三元复合物。这导致细胞内相关激酶 JAK1 和 TYK2 相互靠近，它们相互交叉磷酸化相关受体链以及转录信号转导和激活因子，后者激活 IFN 刺激的基因。虽然 I 型 IFN 和 III 型 IFN 的生物反应有明显的相似之处，但它们在趋向性、活性调节和诱导免疫反应方面也存在差异。最近的研究进展深入探讨了这些受体的结构组装及其功能影响，以及小鼠和人类系统在这些方面的差异。
期刊介绍：
Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.
In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.
Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students.
Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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