Return of the forgotten nightmare: Bordetella pertussis uses a more negative Gibbs energy of metabolism to outcompete its host organism

IF 3 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Microbial Risk Analysis Pub Date : 2024-04-01 DOI:10.1016/j.mran.2024.100292

Marko E. Popović , Maja Stevanović , Marijana Pantović Pavlović

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引用次数: 0

Abstract

Pertussis (whooping cough) has been nearly eradicated during the 20th century, first of all due to an organized and comprehensive vaccination campaign that lasted for decades. Generations of doctors educated in Serbia (and other countries) rarely had an opportunity to see the clinical picture of pertussis. However, during 2023, the number of registered cases of pertussis in Serbia has increased several times. This is why the health authorities were forced to declare danger of an epidemic. During 2023, in Belgrade, around 1000 cases were registered. During the two months of 2024, 400 cases were registered. Some of them have ended with lethal outcome. This paper reports for the first time the biosynthesis reaction and thermodynamic properties of biosynthesis (enthalpy, entropy and Gibbs energy) of Bordetella pertussis, the cause of whooping cough. Moreover, a mechanistic model of multiplication of B. pertussis was developed. The mechanistic model was related to the pathogenesis of pertussis.

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被遗忘的噩梦再次降临：百日咳博德特菌利用更负的吉布斯代谢能战胜宿主生物

百日咳（百日咳）在 20 世纪几乎被根除，这首先要归功于持续数十年的有组织的全面疫苗接种运动。在塞尔维亚（和其他国家）接受教育的几代医生很少有机会看到百日咳的临床表现。然而，在 2023 年期间，塞尔维亚登记的百日咳病例数增加了数倍。因此，卫生当局被迫宣布有流行病的危险。2023 年期间，贝尔格莱德登记的病例约为 1 000 例。在 2024 年的两个月里，登记了 400 个病例。其中一些病例最终导致死亡。本文首次报道了百日咳病原体百日咳杆菌的生物合成反应和生物合成的热力学特性（焓、熵和吉布斯能）。此外，还建立了百日咳杆菌的繁殖机理模型。该机理模型与百日咳的发病机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial Risk Analysis Medicine-Microbiology (medical)

CiteScore

5.70

自引率

7.10%

发文量

审稿时长

52 days

期刊介绍： The journal Microbial Risk Analysis accepts articles dealing with the study of risk analysis applied to microbial hazards. Manuscripts should at least cover any of the components of risk assessment (risk characterization, exposure assessment, etc.), risk management and/or risk communication in any microbiology field (clinical, environmental, food, veterinary, etc.). This journal also accepts article dealing with predictive microbiology, quantitative microbial ecology, mathematical modeling, risk studies applied to microbial ecology, quantitative microbiology for epidemiological studies, statistical methods applied to microbiology, and laws and regulatory policies aimed at lessening the risk of microbial hazards. Work focusing on risk studies of viruses, parasites, microbial toxins, antimicrobial resistant organisms, genetically modified organisms (GMOs), and recombinant DNA products are also acceptable.