Bacterial Endospore Based Wearable Biosensors for Selective and Sensitive Glucose Monitoring

Abstract

We present a groundbreaking non-invasive, wearable glucose biosensor offering long-term stability, high selectivity, and biocompatibility at low cost. Utilizing bacterial endospores as novel bioreceptors, our sensor exhibits unprecedented robustness, maintaining viability for extended periods without optimized storage conditions. Upon contact with glucose on human skin, these endospores germinate, initiating a microbial process that converts glucose into electrical signals directly correlating with glucose levels. This biosensor discriminates glucose effectively amidst other skin-emitted substances, ensuring precise monitoring. The electrical signals are converted by an integrated circuit, providing a visual LED alert at specific glucose thresholds.