The Smallest-Footprint Multi-Cells Microfluidics Separation Channel Modeling Via Integration of Lift and Dielectrophoretic (DEP) Forces

Abstract

Active and passive separation based microfluidic systems play a significant role in isolating desire cells among others. Various microfluidic systems have been developed and utilized in biomedical cell separation, requiring effective systems with high throughput that have efficient capabilities to isolate different cells and particles effectively and simultaneously. This paper demonstrates the smallest curvature microfluidic channel that separates different blood particles: red and white blood cells, platelets, antigen-presenting cells, and circulating tumor cells at minimum footprint and power consumption. The proposed work utilizes and integrates passive lift and active dielectrophoretic forces using three different electrode shapes that achieves a successful separation of different blood cells to five different outlets.