Ferritin and mortality in hemodialysis patients with COVID-19: A systematic review and meta-analysis

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.4103/apjtm.apjtm_624_23

Ni Wayan Anantika Riani, I. Widiana, Y. Kandarini

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Abstract

To investigate the difference in serum ferritin levels between deceased and surviving regular hemodialysis patients with COVID-19. We conducted a systematic search across four databases following the PRISMA statement guidelines. Studies reporting ferritin levels and mortality of regular hemodialysis patients with COVID-19 were included. Employing the random-effects model, we performed a meta-analysis to determine the mean difference in serum ferritin levels between the studied groups, along with their corresponding 95% confidence intervals. The meta-analysis was carried out using Review Manager 5.4 and Stata 16. A total of 1 013 patients from seven studies were included in this study. Our meta-analysis showed higher mean serum ferritin in the deceased compared to surviving regular hemodialysis patients with COVID-19, with a mean difference of 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]. Our study found a higher mean of serum ferritin levels in the deceased compared to surviving regular hemodialysis patients with COVID-19.

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铁蛋白与 COVID-19 血液透析患者的死亡率：系统回顾和荟萃分析

研究 COVID-19 已故和存活的定期血液透析患者血清铁蛋白水平的差异。我们按照 PRISMA 声明指南在四个数据库中进行了系统检索。纳入了报告 COVID-19 定期血液透析患者铁蛋白水平和死亡率的研究。我们采用随机效应模型进行了荟萃分析，以确定研究组间血清铁蛋白水平的平均差异及其相应的 95% 置信区间。荟萃分析使用 Review Manager 5.4 和 Stata 16 进行。本研究共纳入了 7 项研究中的 1 013 名患者。我们的荟萃分析表明，与存活的常规血液透析患者相比，COVID-19 死亡患者的平均血清铁蛋白更高，平均差异为 449.43 ng/mL [95% CI (244.07, 654.80), P<0.000 1; I 2=58%, P=0.003]。我们的研究发现，与COVID-19存活的普通血液透析患者相比，已故患者的血清铁蛋白平均水平更高。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.